artículo académico

• Snakebite envenoming in French Guiana: Assessment of the preclinical efficacy against the venom of Bothrops atrox of two polyspecific antivenoms.  Toxicon.  173:1-4. 2020
• A functional role for snake envenomation wound exudate in local and systemically observed pathophysiology.  Toxicon.  158:S1. 2019
• Antivenom against Vipera berus is effective against Macrovipera lebetina.  Toxicon.  159:S32. 2019
• Bio-interfactants as double-sided tapes for Graphene Oxide.  Nanoscale.  11:4236-4247. 2019
• Case Report: Hemothorax in Envenomation by the Viperid Snake Bothrops asper.  The American Society of Tropical Medicine and Hygiene.  100:714-716. 2019
• Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom.  Toxicology in Vitro.  58:97-109. 2019
• Cocktails of human monoclonal IgG antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba venom in vivo.  Toxicon.  159:S5-S6. 2019
• Coordinated hunting behaviors of mixed-species groups of piscivores and associated species at Isla del Coco National Park (Eastern Tropical Pacific).  Blackburn, Nicholas B..  17:367-379. 2019
• Deficient skeletal muscle regeneration after injury induced by a Clostridium perfringens strain associated with gas gangrene.  Infection and Immunity.  2019
• Defining the pathogenic threat of envenoming by South African shield-nosed and coral snakes (genus Aspidelaps), and revealing the likely efficacy of available antivenom.  Journal of Proteomics.  198:186-198. 2019
• Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.  Toxicon.  159:S17-S18. 2019
• Escuela de Educación Física y Deportes, UCR.  Toxicon.  159:61-62. 2019
• First look into the venom of Roatan Island's critically endangered coral snake Micrurus ruatanus: Proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom.  Journal of Proteomics.  198:177-185. 2019
• Global Availability of Antivenoms: The Relevance of Public Manufacturing Laboratories.  Toxins.  11:E5. 2019
• Harnessing human monoclonal antibodies for neutralisation of dendrotoxins in a murine model.  Toxicon.  159:S14. 2019
• Harnessing phage display technology for discovery of human IgGs targeting clinically relevant toxins from the venom of the Central American coral snake (Micrurus nigrocinctus).  Toxicon.  158:S45. 2019
• Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu.  Toxicon.  18:1063-1069. 2019
• Monoclonal human IgGs capable of neutralizing elapid neurotoxins in vivo.  Toxicon.  158:S44. 2019
• Nephrotoxicity induced by the venom of Hypnale hypnale from Sri Lanka: Studies on isolated perfused rat kidney and renal tubular cell lines.  Toxicon.  165:40-46. 2019
• Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2.  Toxicon.  157:1-7. 2019
• Phylovenomics of Daboia russelii across the indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka.  Journal of Proteomics.  207:103443. 2019
• Proanthocyanidin-chitosan composite nanoparticles prevent bacterial invasion and colonization of gut epithelial cells by extra-intestinal pathogenic Escherichia coli.  International Journal of Biological Macromolecules.  135:630-636. 2019
• Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening.  Toxins.  11:170. 2019
• Proteomic Analysis of Human Blister Fluids Following Envenomation by Three Snake Species in India: Differential Markers for Venom Mechanisms of Action.  Toxins.  11:246. 2019
• Site mutation of residues in a loop surrounding the active site of a P[sbnd]I snake venom metalloproteinase abrogates its hemorrhagic activity.  Biochemical and Biophysical Research Communications.  512:859-863. 2019
• Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom.  Toxicon: X.  1. 2019
• Vipera berus berus Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom.  Toxins.  11:90. 2019
• A Snake Venom-Secreted Phospholipase A 2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis.  Mediators of Inflammation.  3:1-13. 2018
• A Synthetic Biology approach for consistent production of plant‐made recombinant polyclonal antibodies against snake venom toxins.  Plant Biotechnology Journal.  16:727-736. 2018
• A novel pentameric phospholipase A 2 myotoxin (PophPLA 2 ) from the venom of the pit viper Porthidium ophryomegas.  International Journal of Biological Macromolecules.  118:1-8. 2018
• Analgesic effect of morphine and tramadol in standard toxicity assays in mice injected with venom of the snake Bothrops asper.  Toxicon.  154:35-41. 2018
• Antivenoms: Life-saving drugs for envenomings by animal bites and stings.  Toxicon.  150:11-12. 2018
• Aportes del modelo de Yrjö Engeström al desarrollo teórico de la docencia universitaria.  Journal of Proteomics.  181:104-117. 2018
• Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis.  Pharmaceutical and Pharmacological Letters.  10:115-118. 2018
• Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis.  Pharmaceutical and Pharmacological Letters.  10:115-118. 2018
• Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity.  Scientific Reports.  8. 2018
• Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii.  Biochimie.  10:61-66. 2018
• Characterization of the Skin Microbiota of the Cane Toad Rhinella cf. marina in Puerto Rico and Costa Rica.  Frontiers in Microbiology.  8:1-13. 2018
• Comparative study of venoms of newborn and adult specimens of Bothrops asper | Estudio comparativo de venenos de ejemplares recién nacidos y adultos de Bothrops asper..  Revista de Biología Tropical.  28:341-351. 2018
• Current technology for the industrial manufacture of snake antivenoms.  Toxicon.  151:63-73. 2018
• Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom.  Toxins.  10:479. 2018
• Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom.  Toxicon.  10:380-781. 2018
• Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom.  Toxicon.  10:380-781. 2018
• Effect of Thermo-Treatment on the Physical and Mechanical, Color, Fungal Durability of Wood of Tectona Grandis and Gmelina Arborea from Forest Plantations.  Materials Science.  24:59-68. 2018
• Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis.  PLoS Neglected Tropical Diseases.  12:e0006736. 2018
• High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays.  Scientific Reports.  6:36629. 2018
• Improving the control of snakebite envenomation in Latin America and the Caribbean: a discussion on pending issues.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  112:523-526. 2018
• In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies.  Nature Communications.  9:3928. 2018
• Innovative Immunization Strategies for Antivenom Development.  Toxins.  10:452. 2018
• Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: Functional profiles of hemolytic and non-hemolytic isoforms.  Toxicology Letters.  286:39-47. 2018
• Isolation from a polyvalent antivenom of antibodies to a myotoxin in Bothrops asper snake venom.  Toxicon.  23:807-813. 2018
• Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases.  Journal of Proteomics.  317:1781-1794. 2018
• Light Emitting Diode (LED) therapy reduces local pathological changes induced by Bothrops asper snake venom.  Toxicon.  152:95-102. 2018
• Metalloproteinases in disease: identification of biomarkers of tissue damage through proteomics.  Expert Review of Proteomics.  15:967-982. 2018
• Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A2: Role of negatively charged phospholipids as potential membrane binding sites.  Archives of Biochemistry and Biophysics.  148:56-64. 2018
• Olivo, Renata do A..  Toxicon.  146:87-90. 2018
• Oral Microbiota of the Snake Bothrops lanceolatus in Martinique.  International Journal of Environmental Research and Public Health.  15:2122. 2018
• Preclinical assessment of the neutralizing efficacy of antivenoms in Latin America and the Caribbean: A review.  Toxicon.  146:138-150. 2018
• Preclinical evaluation of the neutralizing ability of a monospecific antivenom for the treatment of envenomings by Bothrops lanceolatus in Martinique.  Toxicon.  148:50-55. 2018
• Prevalence of the fungal pathogen Batrachochytrium dendrobatidis in amphibians of Costa Rica predated first-known epizootic.  BioRxiv.  2018
• Pros and cons of different therapeutic antibody formats for recombinant antivenom development.  Toxicon.  146:151-175. 2018
• Proteomic studies on Micrurus (coral snakes) venom reveal a dichotomy of phenotypes.  Toxicon.  150:319-320. 2018
• Publisher Correction: In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies.  Nature Communications.  9. 2018
• Robust PI/PID controllers for load disturbance based on direct synthesis.  ISA Transactions.  59:158-162. 2018
• Signaling pathways involved in zymosan phagocytosis induced by two secreted phospholipases A2isolated from Bothrops asper snake venom in macrophages.  International Journal of Biological Macromolecules.  113:575-582. 2018
• Snakebite envenomation in the Caribbean: The role of medical and scientific cooperation.  PLoS Neglected Tropical Diseases.  12:e0006441. 2018
• Systemic vascular leakage induced in mice by Russell’s viper venom from Pakistan.  Scientific Reports.  8:16088. 2018
• T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study.  PLoS ONE.  13. 2018
• The imbroglio of the physiological Cra effector clarified at last.  Molecular Microbiology.  109:273-277. 2018
• The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.  Journal of Proteomics.  172:173-189. 2018
• The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms.  CommunicationsBiology.  1:34. 2018
• Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms.  Toxicon.  148:123-131. 2018
• Venom gland transcriptomics and microRNA profiling of juvenile and adult yellow-bellied sea snake, Hydrophis platurus, from Playa del Coco (Guanacaste, Costa Rica).  Toxicon.  153:96-105. 2018
• Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms.  Toxins.  15:178. 2018
• Yeast screening and cell immobilization on inert supports for ethanol production from cheese whey permeate with high lactose loads.  PLoS ONE.  13:e0210002. 2018
• An improved technique for the assessment of venom-induced haemorrhage in a murine model.  Toxicon.  139:87-93. 2017
• Anthodiscus chocoensis Prance, especie forestal en peligro crítico de extinción en Costa Rica.  Protein and Peptide Letters.  16:53-69. 2017
• Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect.  Bocaparvovirus, Erythroparvovirus and Tetraparvovirus in New World Monkeys from Central America.  23:18. 2017
• Brucella Genetic Variability in Wildlife Marine Mammals Populations Relates to Host Preference and Ocean Distribution.  Genome Biology and Evolution.  9:1901-1912. 2017
• Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports.  Journal of Medical Case Reports.  11:352. 2017
• Changes in the electrophoretic pattern of the venom of the bushmaster (Lachesis muta stenophrys) stored under various conditions | Cambios en el patrón electroforético del veneno de la serpien te cascabel muda (Lachesis muta stenophrys) almacenado bajo diferen tes condiciones..  Revista de Biología Tropical.  33:63-65. 2017
• Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles).  Toxicon.  137:158-167. 2017
• Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles).  Toxicon.  137:158-167. 2017
• Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus).  Toxicon.  127:106-111. 2017
• Cross-reactivity and cross-immunomodulation between venoms of the snakes Bothrops asper , Crotalus simus and Lachesis stenophrys , and its effect in the production of polyspecific antivenom for Central America.  Toxicon.  138:43-48. 2017
• Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms.  PLoS Neglected Tropical Diseases.  11:e0005793. 2017
• Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping.  PLoS Neglected Tropical Diseases.  11:e0005768. 2017
• Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis.  Investigación y desarrollo en ciencias exactas y naturales.  107:187-196. 2017
• Detection of an undescribed Rickettsia sp. in Ixodes boliviensis from Costa Rica.  Ticks and Tick-borne Diseases.  5:883-886. 2017
• Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.  Toxicology Letters.  280:159-170. 2017
• Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests.  Bioorganic & Medicinal Chemistry Letters.  27:2018-2022. 2017
• Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.  Biomedicine & Pharmacotherapy.  90:740-743. 2017
• Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.  Biomedicine & Pharmacotherapy.  90:740-743. 2017
• Effect of steam-drying treatment on moisture content, drying rate, color and drying defects in juvenile wood of Tectona grandis from fast-growth plantations.  Drying Technology.  35:1832-1842. 2017
• Estudio preliminar de la obtención de compuestos híbridos de quitosano y polifenoles derivados de lignina a partir de subproductos agropecuarios y pesquería de camarón.  Revista Científica de la Facultad de Ciencias Químicas y Farmacia.  27:32-42. 2017
• Evaluation of systemic and mucosal anti-HPV16 and anti-HPV18 antibody responses from vaccinated women.  Journal of Proteomics.  150:201-215. 2017
• Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A 2 from the Central American coral snake, Micrurus nigrocinctus.  PeerJ.  5:e2924. 2017
• Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca.  Journal of Proteomics.  150:98-108. 2017
• Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol.  Toxicon.  133:123-126. 2017
• Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom.  Toxicon.  132:55-61. 2017
• Human Brucella melitensis infections in southern Vietnam.  Clinical Microbiology and Infection.  23:788-790. 2017
• Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.  European Journal of Biochemistry.  267:5191-5197. 2017
• Interfactant action of an amphiphilic polymer upon directing graphene oxide layer formation on sapphire substrates.  Applied Adhesion Science.  5:10. 2017
• PROPUESTA DE INCORPORACIÓN DE LA NANOTECNOLOGÍA EN LA EDUCACIÓN FORMAL MEDIA EN COSTA RICA.  Revista MOMENTO.  193:17-28. 2017
• Peptidomimetic hydroxamate metalloproteinase inhibitors abrogate local and systemic toxicity induced by Echis ocellatus (saw-scaled) snake venom.  Toxicon.  135:40-49. 2017
• Physicochemical characterization of commercial freeze-dried snake antivenoms.  Toxicon.  126:32-37. 2017
• Physicochemical characterization of jicaro seeds (Crescentia alata HBK): A novel protein and oleaginous seed.  Journal of Food Composition and Analysis.  56:84-92. 2017
• Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead.  Toxins.  9:163. 2017
• Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa.  PLoS Neglected Tropical Diseases.  11:e0005969. 2017
• Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus).  Journal of Proteomics.  158:62-72. 2017
• Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: Are there additional effector mechanisms involved?.  PeerJ.  2014. 2017
• Snakebite envenoming.  Nature Reviews Disease Primers.  3. 2017
• Steps to overcome the North-South divide in research relevant to climate-change policy and practice.  Nature Climate Change.  7:21-27. 2017
• Understanding the Snake Venom Metalloproteinases: An Interview with Jay Fox and José María Gutiérrez.  Toxins.  9:33. 2017
• Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle.  PLoS ONE.  11. 2016
• Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2.  Toxicology Letters.  257:60-71. 2016
• Diez reglas sencillas para científicos con aspiraciones en países de bajos ingresos.  Reportes Científicos FACEN.  4:82-85. 2016
• International Journal of Food Sciences and Nutrition.  Toxins.  8:138. 2016
• A comprehensive view of the structural and functional alterations of extracellular matrix by snake venom metalloproteinases (SVMPs): Novel perspectives on the pathophysiology of envenoming.  Toxins.  8. 2016
• A polyspecific antivenom for Sri Lanka: First to include Hypnale.  Toxicon.  117:103. 2016
• Biochemical and biological characterization of Bothriechis schlegelii snake venoms from Colombia and Costa Rica.  Experimental Biology and Medicine.  241:2075-2085. 2016
• Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors.  Cellular and Molecular Life Sciences.  385:1718-1728. 2016
• Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest.  Journal of Proteomics.  135:73-89. 2016
• De León Castrejón, Tirza.  Toxicon.  109:51-62. 2016
• Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom.  Toxicon.  120:1-8. 2016
• Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom.  Toxicon.  122:152-159. 2016
• Environmental quality of a cultural landscape 75 years after its foundation: the Banana City of Golfito, Costa Rica.  Cuadernos de Investigación UNED (UNED Research Journal).  8:85-92. 2016
• From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy.  Current Pharmaceutical Design.  22:5270-5293. 2016
• Hemorrhage caused by snake venom metalloproteinases: A journey of discovery and understanding.  Toxins.  8:93. 2016
• Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment.  American Journal of Obstetrics and Gynecology.  215:212.e1-212.e15. 2016
• Inequality: Span the global divide.  Nature.  539. 2016
• Journal of Clinical Immunology.  Revista de Biología Tropical.  65. 2016
• La importancia de fortalecer la generación y la transmisión de conocimiento científico-tecnológico en Odontología.  Odovtos - International Journal of Dental Sciences.  18:9-12. 2016
• Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis.  PLoS Neglected Tropical Diseases.  10. 2016
• Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab')2 and whole IgG antivenoms.  Toxicology Letters.  241:175-183. 2016
• Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif.  Toxins.  8:292. 2016
• Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics.  Toxicon.  119:280-288. 2016
• Priority Actions and Progress to Substantially and Sustainably Reduce the Mortality, Morbidity and Socioeconomic Burden of Tropical Snakebite.  Toxins.  8:351. 2016
• Production of monovalent anti-Bothrops asper antivenom: development of immune response in horses and neutralizing ability..  Revista de Biología Tropical.  36:511-517. 2016
• Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).  Journal of Proteomics.  136:248-261. 2016
• Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.  Toxicon.  122:7-25. 2016
• Viperid Envenomation Wound Exudate Contributes to Increased Vascular Permeability via a DAMPs/TLR-4 Mediated Pathway.  Toxins.  8:349. 2016
• Zika Virus (ZIKV): A New Emerging Pathogen Transmitted by Aedes Mosquitoes (Diptera: Culicidae) in the Latin American subcontinent..  Vector Biology Journal.  1. 2016
• Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms.  Toxicon.  108:80-83. 2015
• Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins.  Toxicon.  99:23-35. 2015
• A Call for Incorporating Social Research in the Global Struggle against Snakebite.  PLoS Neglected Tropical Diseases.  9. 2015
• A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line.  Toxicon.  45:651-660. 2015
• Bites and envenomations by colubrid snakes in Mexico and Central America.  Journal of Toxicology - Toxin Reviews.  21:105-115. 2015
• Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.  Thrombosis and Haemostasis.  85:710-715. 2015
• Chikungunya: un virus que nos acecha [Chikungunya: a threatening virus].  Acta Médica Costarricense.  57:7-15. 2015
• Efectos locales inducidos por el veneno de la serpiente coral Micrurus nigrocinctus en ratón blanco.  Toxicon.  18:633-639. 2015
• Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria.  Toxicon.  106:97-107. 2015
• Extracts of renealmia alpinia (rottb.) MAAS protect against lethality and systemic hemorrhage induced by bothrops asper venom: Insights from a model with extract administration before venom injection.  Toxins.  7:1532-1543. 2015
• First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis.  Toxicon.  93:144-154. 2015
• Irradiación subletal de fibroblastos murinos 3T3 con rayos X para su utilización como capa celular alimentadora.  Tecnología en Marcha.  28:15-26. 2015
• Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom.  Toxicon.  103:99-105. 2015
• MmTX1 and MmTX2 from coral snake venom potently modulate receptor activity modulate GABAa receptor activity.  Proceedings of the National Academy of Sciences of the United States of America.  112:E891-E900. 2015
• Phospholipase A<inf>2</inf> enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis.  Chemico-Biological Interactions.  240:30-36. 2015
• Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step.  Biologicals.  43:37-46. 2015
• Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score.  Toxicon.  104:43-45. 2015
• Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids.  Toxicon.  107:217-233. 2015
• Snakebites are associated with poverty, weather fluctuations, and El Niño.  Epidemiology.  1:e1500249. 2015
• Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage.  PLoS Neglected Tropical Diseases.  9. 2015
• Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development.  Journal of Proteomics.  119:126-142. 2015
• Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil.  Journal of Proteomics.  114:93-114. 2015
• A Comparison of four Methods to Evaluate the Butterfly Abundance. Using a Tropical Community.  Journal of Immunotoxicology.  11:241-243. 2014
• A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming.  Bulletin of the World Health Organization.  92:526-532. 2014
• A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom.  Toxicon.  87:81-91. 2014
• An asp49 phospholipase A² from snake venom induces cyclooxygenase-2 expression and prostaglandin E² production via activation of NF- κ B, p38MAPK, and PKC in macrophages.  Mediators of Inflammation.  2014. 2014
• An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes.  Toxicon.  30:815-823. 2014
• Anticomplementary activity of horse IgG and F(ab')2 antivenoms.  American Journal of Tropical Medicine and Hygiene.  90:574-584. 2014
• Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.  American Journal of Tropical Medicine and Hygiene.  91:887-894. 2014
• Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment.  Lancet Diabetes Diabetes & Endocrinology.  2:634-647. 2014
• Chemical Modification of Graphene via Hyperthermal Molecular Reaction.  Journal of the American Chemical Society.  136:13482-13485. 2014
• Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka.  Journal of Proteomics.  110:209-229. 2014
• Correction: Critical role of TLR2 and MyD88 for functional response of macrophages to a group iia-secreted phospholipase A2 from snake venom (PLoS ONE (2014) 9, 4 (e93741) DOI: 10.1371/journal.pone.0105241).  PLoS ONE.  9. 2014
• Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-secreted phospholipase A2from snake venom.  PLoS ONE.  9. 2014
• Current challenges for confronting the public health problem of snakebite envenoming in Central America.  Bocaparvovirus, Erythroparvovirus and Tetraparvovirus in New World Monkeys from Central America.  20. 2014
• Enlace al artículo.  Toxicon.  46:806-813. 2014
• Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test.  Toxicon.  90:56-63. 2014
• Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III.  PLos Pathogens.  10. 2014
• Immunological profile of antivenoms: Preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays.  Journal of Proteomics.  105:340-350. 2014
• Industrial Production and Quality Control of Snake Antivenoms.  Toxinology.  24:1-22. 2014
• Instantly investigating the adsorption of polymeric corrosion inhibitors on magnesium alloys by surface analysis under ambient conditions.  Journal of Surface Engineered Materials and Advanced Tecnology.  4:282-294. 2014
• Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus.  Biochimie.  107:376-384. 2014
• Omics meets biology: Application to the design and preclinical assessment of antivenoms.  Toxins.  6:3388-3405. 2014
• Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: An antivenomics and neutralization study.  Journal of Proteomics.  110:198-208. 2014
• Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom.  Journal of Proteomics.  96:159-172. 2014
• Reducing the impact of snakebite envenoming in latin America and the Caribbean: Achievements and challenges ahead.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  108:530-537. 2014
• Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo.  PLoS ONE.  9. 2014
• The analgesics morphine and tramadol do not alter the acute toxicity induced by Bothrops asper snake venom in mice.  Toxicon.  81:54-57. 2014
• The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay.  Toxicon.  93:41-50. 2014
• Two color morphs of the pelagic yellow-bellied sea snake, Pelamis platura, from different locations of Costa Rica: Snake venomics, toxicity, and neutralization by antivenom.  Journal of Proteomics.  103:137-152. 2014
• Unravelling a vicious circle: animal feed marketed in Costa Rica contains irregular concentrations of tetracyclines and abundant oxytetracycline-resistant Gram-positive bacteria. .  Food Additives & Contaminants: Part A.  31:1017-1025. 2014
• Venomics of new world pit vipers: Genus-wide comparisons of venom proteomes across agkistrodon.  Journal of Proteomics.  96:103-116. 2014
• Venomous snakes of Costa Rica: Biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics.  Journal of Proteomics.  105:323-339. 2014
• A Lys49 phospholipase A2, isolated from Bothrops asper snake venom, induces lipid droplet formation in macrophages which depends on distinct signaling pathways and the C-terminal region..  BioMed Research International.  807-982. 2013
• Antivenom for snakebite envenoming in Sri Lanka: The need for geographically specific antivenom and improved efficacy.  Toxicon.  69:90-97. 2013
• Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics.  Toxicon.  69:168-179. 2013
• Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods.  Biologicals.  41:93-97. 2013
• Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom.  Toxicon.  63:32-43. 2013
• Bothrops asper Metalloproteinase BaP1.  Handbook of Proteolytic Enzymes: Third Edition.  1:984-987. 2013
• Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico.  Toxicon.  71:84-95. 2013
• Dissolution properties, solid-state transformation and polymorphic crystallization: Progesterone case study.  Pharmaceutical Development and Technology.  19:779-788. 2013
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• Enlace al artículo.  Circulation.  127:143-152. 2013
• Enlace al artículo.  Circulation.  127:143-152. 2013
• Immune modulation by genetic modification of dendritic cells with lentiviral vectors.  Virus Research.  176:1-15. 2013
• Integrated "omics" profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus.  BMC Genomics.  2013
• Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies.  Journal of Proteomics.  1:103-121. 2013
• Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A2 myotoxins - Distinct mechanisms of action.  FEBS Journal.  280:3878-3886. 2013
• New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India.  Indian Journal of Medical Research.  138:38-59. 2013
• Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms.  Toxicon.  76:63-76. 2013
• Pedro Morera Villalobos (30 abril 1933-19 setiembre 2012).  Journal of Proteome Research.  11:1382-1390. 2013
• Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase.  Journal of Proteomics.  80:250-267. 2013
• Role of the animal model on the pharmacokinetics of equine-derived antivenoms.  Toxicon.  70:9-14. 2013
• Scattering of Light by Colloidal Aluminosilicate Particles Produces the Unusual Sky-Blue Color of Río Celeste (Tenorio Volcano Complex, Costa Rica).  PLoS ONE.  8. 2013
• Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis.  Journal of Proteomics.  89:112-123. 2013
• Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model.  Toxicon.  63:19-31. 2013
• The Need for Full Integration of Snakebite Envenoming within a Global Strategy to Combat the Neglected Tropical Diseases: The Way Forward.  PLoS Neglected Tropical Diseases.  7. 2013
• Using Geographical Information Systems to Identify Populations in Need of Improved Accessibility to Antivenom Treatment for Snakebite Envenoming in Costa Rica.  PLoS Neglected Tropical Diseases.  7. 2013
• Why myotoxin-containing snake venoms possess powerful nucleotidases?.  Biochemical and Biophysical Research Communications.  430:1289-1293. 2013
• 160. Role of SVMPs, Matrikines and TLR4 in Snake Venom Induced Edema and Inflammation.  Toxicon.  60:177. 2012
• 192. Action of Venom Metalloproteinases on Basement Membranes: Pathogenesis of Hemorrhage and Blistering in Snakebite Envenomings.  Toxicon.  60:194-194. 2012
• 210. Understanding the Preclinical Efficacy Profile of Antivenoms: From the Lethality Potency Assay to Antivenomics.  Toxicon.  60:203. 2012
• 222. Molecular Mechanisms Involved in PGE2 Release Induced by the Snake Venom Metalloproteinase BaP1 in Synoviocytes.  Toxicon.  60:209-209. 2012
• A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling.  Cell Death and Disease.  3. 2012
• Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B.  Acta Tropica.  124:126-132. 2012
• Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.  Archives of Biochemistry and Biophysics.  418:13-24. 2012
• Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity.  Journal of Proteomics.  75:2128-2140. 2012
• Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia.  Toxicon.  59:344-355. 2012
• Efficacy of IgG and F(ab′) 2 antivenoms to neutralize snake venom-induced local tissue damage as assessed by the proteomic analysis of wound exudate.  Journal of Proteome Research.  11:292-305. 2012
• First record of the sea anemone Anthopleura nigrescens (Cnidaria: Actiniaria: Actiniidae) on the Pacific coast of Central America.  Marine Biodiversity Records.  5:1-3. 2012
• Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture.  Muscle and Nerve.  47:202-212. 2012
• Identification of new snake venom metalloproteinase inhibitors using compound screening and rational peptide design.  ACS Medicinal Chemistry Letters.  3:540-543. 2012
• Improving antivenom availability and accessibility: Science, technology, and beyond.  Toxicon.  60:676-687. 2012
• In vitro antiplasmodial activity of phospholipases A2 and a phospholipase homologue isolated from the venom of the snake Bothrops asper.  Toxins.  4:1500-1516. 2012
• Isolation and biochemical, functional and structural characterization of a novel l-amino acid oxidase from Lachesis muta snake venom.  Toxicon.  60:1263-1276. 2012
• La situación de los antivenenos liofilizados en América Latina: Aspectos tecnológicos y de salud pública.  Gazeta Médica da Bahia.  82:106-109. 2012
• Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation.  Biologicals.  40:129-133. 2012
• Purification of IgG and albumin from human plasma by aqueous two phase system fractionation.  Biotechnology Progress.  28:1005-1011. 2012
• Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols.  Toxicon.  60:688-699. 2012
• Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses.  Journal of Proteomics.  75:5628-5645. 2012
• Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.  Toxicon.  59:592-599. 2012
• Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights.  Journal of Proteomics.  75:1675-1689. 2012
• Standardization of assays for testing the neutralizing ability of antivenoms.  Toxicon.  28:1127-1129. 2012
• A group IIA-secreted phospholipase A 2 from snake venom induces lipid body formation in macrophages: The roles of intracellular phospholipases A 2 and distinct signaling pathways.  Journal of Leukocyte Biology.  90:155-166. 2011
• A phospholipase A2 from Bothrops asper snake venom activates neutrophils in culture: Expression of cyclooxygenase-2 and PGE2 biosynthesis.  Toxicon.  57:288-296. 2011
• Antivenoms for snakebite envenomings.  Inflammation and Allergy - Drug Targets.  10:369-380. 2011
• Antivenoms for the treatment of snakebite envenomings: The road ahead.  Biologicals.  39:129-142. 2011
• Atherosclerosis.  Journal of Proteome Research.  10:1266-1280. 2011
• Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom.  Toxicon.  58:558-564. 2011
• Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms.  Toxicon.  57:237-243. 2011
• Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa.  Journal of Proteomics.  74:1735-1767. 2011
• Expanded Very Large Array Continuum Observations toward Hot Molecular Core Candidates.  The Astrophysical Journal Letters.  739:1-4. 2011
• High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry.  Journal of Proteomics.  74:401-410. 2011
• Immune response towards snake venoms.  Inflammation and Allergy - Drug Targets.  10:381-398. 2011
• Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper.  Cell Biochemistry and Function.  29:365-370. 2011
• Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica.  Toxicon.  38:1429-1441. 2011
• Phospholipases A2 from viperidae snake venoms: How do they induce skeletal muscle damage?.  Acta Chimica Slovenica.  58:647-659. 2011
• Preclinical evaluation of caprylic acid-fractionated igg antivenom for the treatment of taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea.  PLoS Neglected Tropical Diseases.  5. 2011
• Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica.  Journal of Proteomics.  75:655-667. 2011
• Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management.  Journal of Proteomics.  74:510-527. 2011
• Solvents derived from glycerol modify classical regioselectivity in the enzymatic synthesis of disaccharides with Biolacta β-galactosidase.  Green Chemistry.  13:2810-2817. 2011
• The struggle of neglected scientific groups: Ten years of netropica efforts to promote research in tropical diseases in central america.  PLoS Neglected Tropical Diseases.  5. 2011
• Universidad de París Sur (Paris XI), Francia.  PLoS ONE.  6. 2011
• Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).  Journal of Proteome Research.  10:1816-1827. 2011
• Ab-initio Hamiltonian approach to light nuclei and to quantum field theory.  Pramana.  75:39-49. 2010
• Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.  American Journal of Tropical Medicine and Hygiene.  82:1194-1201. 2010
• Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities.  Investigación y desarrollo en ciencias exactas y naturales.  1:8-17. 2010
• Backbone flexibility controls the activity and specificity of a protein-protein interface – specificity in snake venom metalloproteases (SVMPs).  Journal of the American Chemical Society.  132:10330-10337. 2010
• Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain.  Proceedings of the National Academy of Sciences of the United States of America.  107:14140-14145. 2010
• Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: Effects on enzymatic and pharmacological properties.  Toxicon.  35:241-252. 2010
• Consultorías en ciencias de la salud.  Toxicon.  55:642-645. 2010
• Desarrollo de las universidades públicas de Latinoamérica: una visión alternativa al modelo economicista de rentabilidad / Development of public universities in latin america: an alternative perspective to the economicist model of profitability.  Actualidades Investigativas en Educación.  10:1-14. 2010
• Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows.  Biologicals.  38:664-669. 2010
• Isolation and biological characterization of Batx-I, a weak hemorrhagic and fibrinogenolytic PI metalloproteinase from Colombian Bothrops atrox venom.  Toxicon.  56:936-943. 2010
• Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: Biochemical and toxicological characterization.  Biochimie.  92:273-283. 2010
• Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP (R)) for the treatment of viper envenoming in sub-Saharan Africa.  Toxicon.  55:369-374. 2010
• Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms.  Toxicon.  56:980-989. 2010
• Procambarus clarkii as a bioindicator of heavy metal pollution sources in the lower Ebro River and Delta.  Ecotoxicology and Environmental Safety.  73:280-286. 2010
• Snake venomics of bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: Different evolutionary solutions for the same trophic purpose.  Journal of Proteome Research.  9:4234-4241. 2010
• Snake venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America.  Journal of Proteome Research.  9:528-544. 2010
• Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom.  Biologicals.  38:577-585. 2010
• The C-terminal region of a Lys49 myotoxin mediates Ca²⁺ influx in C2C12 myotubes.  Toxicon.  55:590-596. 2010
• Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom.  Biologicals.  37:306-312. 2009
• Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.  Cuadernos de Investigación UNED (UNED Research Journal).  1:233-244. 2009
• Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production.  Biologicals.  37:230-234. 2009
• Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro.  Enlace al artículo.  80:107-114. 2009
• Enlace al artículo.  Journal of Proteome Research.  9:564-577. 2009
• Experimental pathology of local tissue damage induced by Bothrops asper snake venom.  Toxicon.  54:958-975. 2009
• Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom.  Toxicon.  54:976-987. 2009
• Serological Diagnosis of Brucella Infections in Odontocetes.  Clinical and Vaccine Immunology.  16:906-915. 2009
• Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism.  Journal of Proteomics.  73:57-78. 2009
• Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management.  Journal of Proteomics.  72:227-240. 2009
• Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.  Journal of Proteomics.  72:165-182. 2009
• Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature.  Toxicon.  53:609-615. 2009
• The Differential Interaction of Brucella and Ochrobactrum with Innate Immunity Reveals Traits Related to the Evolution of Stealthy Pathogens.  PLoS ONE.  4:e5893. 2009
• The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper.  Archives of Biochemistry and Biophysics.  1:319-325. 2009
• Venoms, venomics, antivenomics.  FEBS Letters.  583:1736-1743. 2009
• Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins.  Journal of Proteome Research.  8:5120-5131. 2009
• A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo).  Acta Tropica.  27:589-596. 2008
• Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom.  Toxicon.  52:754-759. 2008
• Computational biology in Costa Rica: The role of a small country in the global context of bioinformatics.  PLoS Computational Biology.  4. 2008
• Effects of bothrops asper snake venom on lymphatic vessels: Insights into a hidden aspect of envenomation.  PLoS Neglected Tropical Diseases.  2. 2008
• Enlace al artículo.  Journal of Proteomics.  71:46-60. 2008
• Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  102:1115-1119. 2008
• Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper.  Brazilian Journal of Medical and Biological Research.  41:12-17. 2008
• Matchar, David B..  Toxicon.  52:428-439. 2008
• Mortality due to snakebite envenomation in Costa Rica (1993-2006).  Toxicon.  52:530-533. 2008
• Snake venomics and antivenomics of the arboreal neotropical pitvipers bothriechis lateralis and bothriechis schlegelii.  Journal of Proteome Research.  7:2445-2457. 2008
• Snake venomics of Central American pitvipers: Clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi.  Journal of Proteome Research.  7:708-719. 2008
• Snake venomics of the lesser antillean pit vipers bothrops caribbaeus and Bothrops lanceolatus: Correlation with toxicological activities and immunoreactivity of a heterologous antivenom.  Journal of Proteome Research.  7:4396-4408. 2008
• Systemic and local myotoxicity induced by snake venom group II phospholipases A2: Comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue.  Toxicon.  51:80-92. 2008
• Ten simple rules for aspiring scientists in a low-income country.  PLoS Computational Biology.  4. 2008
• Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations.  Biologicals.  35:5-11. 2007
• Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer.  Cancer Epidemiology Biomarkers & Prevention.  16:314-321. 2007
• Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: Evidence of rapid plasma membrane damage and a dual role for extracellular calcium.  Toxicology in Vitro.  21:1382-1389. 2007
• Dissociation of enzymatic and toxic activities by the use of antibodies.  Toxicon.  28:1245-1246. 2007
• El centenario del nacimiento de Clodomiro Picado T. y el retorno del Mutacionismo.  Revista de Biología Tropical.  35:1-4. 2007
• Elleanthus ligularis, a name for a relatively common "new" sepecies of Elleantus sect. chloidelyna.  Lankesteriana.  7:539-542. 2007
• Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease.  The American Journal of Clinical Nutrition.  86:929-937. 2007
• Role of cyclooxygenases in oedema-forming activity of bothropic venoms.  Toxicon.  49:670-677. 2007
• Strengthening antivenom production in Central and South American public laboratories: Report of a workshop.  Toxicon.  49:30-35. 2007
• Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus.  Biochimica et Biophysica Acta - General Subjects.  1770:585-593. 2007
• The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-α and PGE 2-dependent mechanisms.  British Journal of Pharmacology.  151:1254-1261. 2007
• Trends in snakebite envenomation therapy: Scientific, technological and public health considerations.  Current Pharmaceutical Design.  13:2935-2950. 2007
• Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase.  Microvascular Research.  71:55-63. 2006
• Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A 2 homologue on a lymphoblastoid cell line.  Toxicon.  47:75-86. 2006
• Confronting the neglected problem of snake bite envenoming: The need for a global partnership.  PLoS Medicine.  3:0727-0731. 2006
• Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro.  Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology.  143:284-294. 2006
• Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  100:1173-1182. 2006
• Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: The N-terminal region is more important than enzymatic activity.  Biochemistry.  45:5800-5816. 2006
• Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: A biochemical and immunohistochemical study.  Archives of Biochemistry and Biophysics.  455:144-153. 2006
• Pharmacokinetics of whole IgG equine antivenom: Comparison between normal and envenomed rabbits.  Toxicon.  48:255-263. 2006
• Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice.  Inflammation Research.  55:245-253. 2006
• A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.  Journal of Biological Chemistry.  280:26680-26689. 2005
• Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A2.  Toxicon.  46:523-532. 2005
• Anticomplementary activity of equine whole IgG antivenoms: Comparison of three fractionation protocols.  Toxicon.  45:123-128. 2005
• Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells.  Journal of Cellular Biochemistry.  94:520-528. 2005
• Decreased consumption of dried mature beans is positively associated with urbanization and nonfatal acute myocardial infarction.  The Journal of Nutrition.  135:1770-1775. 2005
• Diurnal and acute patterns of postprandial apolipoprotein B-48 in VLDL, IDL, and LDL from normolipidemic humans.  Atherosclerosis.  181:345-351. 2005
• Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom.  International Journal of Experimental Pathology.  86:107-115. 2005
• Hemorrhage induced by snake venom metalloproteinases: Biochemical and biophysical mechanisms involved in microvessel damage.  Toxicon.  45:997-1011. 2005
• Inflammatory events induced by Lys-49 and Asp-49 phospholipases A 2 isolated from Bothrops asper snake venom: Role of catalytic activity.  Toxicon.  45:335-346. 2005
• Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin.  Journal of Molecular Biology.  350:416-426. 2005
• Journal of Pharmaceutical Analysis.  Toxicon.  45:171-178. 2005
• Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A 2 homologues are reduced, but not abolished, by a pH-induced dissociation.  Toxicon.  46:291-296. 2005
• Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: Preclinical assessment.  Acta Tropica.  93:85-95. 2005
• Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: An alternative to the antivenom crisis in Africa.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  99:468-475. 2005
• Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: In vitro and in vivo gene expression analysis of the effects of the toxin.  Archives of Biochemistry and Biophysics.  441:1-15. 2005
• Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage.  Thrombosis and Haemostasis.  94:123-131. 2005
• Assessment of the viral safety of antivenoms fractionated from equine plasma.  Biologicals.  32:115-128. 2004
• Bothrops asper hemorrhagic proteinases.  Handbook of Proteolytic Enzymes: Second Edition.  1:651-654. 2004
• Bothrops asper metalloproteinase BaP1 is inhibited by α 2-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy.  Toxicon.  43:213-217. 2004
• Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA 2 from Bothrops asper venom.  Biochimica et Biophysica Acta - Proteins and Proteomics.  1703:83-85. 2004
• Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: Understanding the role of metalloproteinases in envenomation.  Toxicon.  43:417-424. 2004
• Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity.  Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology.  138:485-492. 2004
• Longitud larval de Hemilucilia segmentaria (Diptera: Calliphoridae) como indicador del intervalo post-mortem en Costa Rica.  Revista Latinoamericana de Derecho Médico y Medicina Legal.  9:37-42. 2004
• Membrane independent activation of fibroblast proMMP-2 by snake venom: Novel roles for venom proteinases.  Toxicon.  44:749-764. 2004
• Quantitative Structure−Activity Relationship of Sesquiterpene Lactones as Inhibitors of the Transcription Factor NF-κB.  Journal of Medicinal Chemistry.  47:6042-6054. 2004
• Snake venom components enhance pain upon subcutaneous injection: An initial examination of spinal cord mediators.  Pain.  111:65-76. 2004
• Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox.  Toxicon.  44:91-101. 2004
• A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa.  Toxicon.  42:35-41. 2003
• Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.  Enlace al artículo.  12:2273-2281. 2003
• Benavides, Yeison.  Toxicon.  42:801-808. 2003
• Enlace al artículo.  Toxicon.  42:405-411. 2003
• Guest editor's foreword.  Toxicon.  42:825-826. 2003
• Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: Comparison between Fab and IgG.  Toxicon.  41:237-244. 2003
• Karyotype study of 5 species of Costa Rican snakes of the colubrid family | Estudios cariológicos de cinco especies de serpientes costarricenses de la familia Colubridae..  Revista de Biología Tropical.  32:263-267. 2003
• Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom.  Muscle and Nerve.  28:449-459. 2003
• Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.  Clinical Pharmacokinetics.  42:721-741. 2003
• Polyspecific snake antivenom may help in antivenom crisis [4].  British Medical Journal.  326:447-448. 2003
• Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes.  Toxicon.  41:851-860. 2003
• Skeletal muscle degeneration induced by venom phospholipases A 2: Insights into the mechanisms of local and systemic myotoxicity.  Toxicon.  42:915-931. 2003
• Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: Isolation, molecular cloning and biological properties.  Biochemical Journal.  346:631-639. 2003
• Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom.  Acta Crystallographica Section D: Biological Crystallography.  58:1034-1035. 2002
• Enlace al artículo.  European Journal of Biochemistry.  269:6052-6062. 2002
• Hemostatic effects induced by Thalassophryne nattereri fish venom: A model of endothelium-mediated blood flow impairment.  Toxicon.  40:1141-1147. 2002
• Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.  Mediators of Inflammation.  11:121-128. 2002
• Las publicaciones de investigación biomédica en la Revista de Biología Tropical.  Revista de Biología Tropical.  50:941-949. 2002
• Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.  Toxicon.  39:1505-1513. 2001
• Comparison between IgG and F(ab′)2 polyvalent antivenoms: Neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions.  Toxicon.  39:793-801. 2001
• Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom.  Archives of Biochemistry and Biophysics.  387:188-196. 2001
• Effects of chemical modifications of crotoxin B, the phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities.  Disturbance compensation on uncertain systems: feedforward control design for stable systems.  33:877-888. 2001
• Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom.  Biochimie.  83:471-479. 2001
• Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom.  Toxicon.  39:1173-1181. 2001
• Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: Comparative toxicological characterization, isolation of a myotoxic phospholipase A2 homologue and neutralization by two antivenoms.  Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology.  129:151-162. 2001
• Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment.  Mediators of Inflammation.  9:213-221. 2000
• Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper.  Biochemical Pharmacology.  60:269-274. 2000
• Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.  Biochimie.  82:755-763. 2000
• Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from Bothrops moojeni (Caissaca) snake venom.  Archives of Biochemistry and Biophysics.  373:7-15. 2000
• A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: Correlation between safety and biochemical characteristics of antivenoms.  Toxicon.  37:895-908. 1999
• Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom.  Toxicon.  37:1297-1312. 1999
• Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.  American Journal of Tropical Medicine and Hygiene.  61:266-271. 1999
• Costa Rican international cooperative biodiversity group: Using insects and other arthropods in biodiversity prospecting.  Pharmaceutical Biology.  37:55-68. 1999
• Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani.  Archives of Biochemistry and Biophysics.  366:177-182. 1999
• Elapid venom toxins: Multiple recruitments of ancient scaffolds.  European Journal of Biochemistry.  259:225-234. 1999
• Electrophysiological characteristics of chronic inflammatory demyelinating polyneuropathy | Perfil electrofisiológico en la polineuropatía crónica desmielinizante inflamatoria.  Revista de Neurologia.  28:353-357. 1999
• Envenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas.  Acta Médica Costarricense.  41:23-29. 1999
• Instituto Clodomiro Picado: Ciencia y tecnología endógenas en la solución de un problema de salud pública en centroamérica.  Interciencia.  24:182-186. 1999
• Neutralización del efecto hemorrágico inducido por veneno de Bothrops asper (Serpentes: Viperidae) por extractos de plantas tropicales.  Revista de Biología Tropical.  47:605-615. 1999
• Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothirops snake venoms.  Toxicon.  37:551-557. 1999
• Structure of a Lys49-Phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper).  Toxicon.  37:371-384. 1999
• Venom composition and diet of the cantil Agkistrodon bilineatus howardgloydi (Serpentes: Viperidae).  Southwestern Naturalist.  44:478-483. 1999
• Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani.  Laboratorio de Plasma para Energía de Fusión y Aplicaciones, TEC.  1384:204-208. 1998
• Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper.  International Journal of Experimental Pathology.  79:245-254. 1998
• Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica.  Toxicon.  36:2021-2027. 1998
• Crystallization and preliminary X-ray diffraction analysis of a Lys49-PLA 2 homologue from Cerrophidion Godmani venom.  Protein and Peptide Letters.  36:121-126. 1998
• Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom.  Toxicon.  36:1529-1538. 1998
• Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo).  Toxicon.  36:1861-1869. 1998
• A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus.  Toxicon.  35:573-581. 1997
• Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper.  Biochemical Journal.  326:853-859. 1997
• Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom.  Toxicon.  35:81-90. 1997
• Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by bothrops asper (terciopelo) snake venom.  Toxicon.  35:1627-1637. 1997
• Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture.  Toxicon.  35:865-877. 1997
• Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture.  Toxicology and Applied Pharmacology.  147:442-447. 1997
• Isolation and characterization of a myotoxic phospholipase A(2) from the venom of the arboreal snake Bothriechis (Bothtops) schlegelii from Costa Rica.  Archives of Biochemistry and Biophysics.  339:260-266. 1997
• Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: Comparison with two commercial antivenoms.  Brazilian Journal of Medical and Biological Research.  30:375-379. 1997
• Snakebite mortality in Costa Rica.  Toxicon.  35:1639-1643. 1997
• Studies on the mechanism of action of myotoxic phospholipases A2 isolated from Bothrops venoms.  Journal of Venomous Animals and Toxins.  3:350. 1997
• Universidad de París VII Denis Diderot, Francia.  Toxicon.  35:1605-1616. 1997
• A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  90:696-700. 1996
• Actividades hemorrágica y coagulante del veneno de Bothrops alternatus de Argentina.  Acta Bioquimica Clinica Latinoamericana.  30:401-405. 1996
• Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from Micrurus nigrocinctus nigrocinctus (coral snake) venom.  Toxicon.  34:369-380. 1996
• Biochemical and biological characterization of Ecudadorian pitviper venoms (genera Bothriechis, bothriopsis, bothrops and Lachesis).  Toxicon.  34:714-717. 1996
• Characterization of α-neurotoxin and phospholipase A2 activities from Micrurus venoms: Determination of the amino acid sequence and receptor-binding ability of the major α-neurotoxin from Micrurus nigrocinctus nigrocinctus.  European Journal of Biochemistry.  238:231-239. 1996
• Effect of adjuvants on the antibody response of mice to Bothrops asper (Terciopelo) snake venom.  Brazilian Journal of Medical and Biological Research.  29:1337-1340. 1996
• Enlace al artículo.  Biochimica et Biophysica Acta - General Subjects.  1245:232-238. 1995
• Evaluacion de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica.  Toxicon.  33:1242-1247. 1995
• Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper.  Toxicon.  33:1103-1106. 1995
• Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo).  Toxicon.  33:19-29. 1995
• Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom.  Blackburn, Nicholas B..  63:186-199. 1995
• Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice.  Toxicon.  33:31-39. 1995
• Skeletal muscle necrosis and regeneration after injection of BaH1, a hemorrhagic metalloproteinase isolated from the venom of the snake Bothrops asper (terciopelo).  Blackburn, Nicholas B..  62:28-41. 1995
• Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom.  Acta Crystallographica Section D: Biological Crystallography.  51:311-317. 1995
• The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom.  Toxicon.  33:679-689. 1995
• A potent antihemorrhagin in the serum of the non-poisonous water snake Natrix tessellata: isolation, characterization and mechanism of neutralization.  Biochimica et Biophysica Acta - General Subjects.  1201:482-490. 1994
• Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect.  Archives of Biochemistry and Biophysics.  312:336-339. 1994
• Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro.  Toxicon.  32:1689-1695. 1994
• Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels.  Toxicon.  32:977-987. 1994
• An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies.  Journal of Immunological Methods.  161:231-237. 1993
• Biological and biochemical activities of Vipera berus (European viper) venom.  Toxicon.  31:743-753. 1993
• Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops Asper (terciopelo) and Bothrops Nummifer (jumping viper).  Toxicon.  31:1061-1064. 1993
• Effects of Bothrops asper (terciopelo) myotoxin III, a basic phospholipase A2, on liposomes and mouse gastrocnemius muscle.  Toxicon.  31:217-222. 1993
• Effects on cultured mammalian cells of myotoxin III, a phospholipase A2 isolated from Bothrops asper (terciopelo) venom.  Biochimica et Biophysica Acta - Molecular Cell Research.  1179:253-259. 1993
• Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper.  Toxicon.  31:1137-1150. 1993
• Toxicity and neutralization of venoms from Peruvian snakes of the genera Bothrops and Lachesis (Serpentes: Viperidae) | Toxicidad y neutralización de venenos ofídicos peruanos de los géneros Bothrops y Lachesis (Serpentes: Viperidae)..  Revista de Biología Tropical.  41:351-357. 1993
• Turbidity of hyperimmune equine antivenom: The role of phenol and serum lipoproteins.  Toxicon.  31:61-66. 1993
• p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities.  Toxicon.  31:1202-1206. 1993
• Calcium ion independent membrane leakage induced by phospholipase-like myotoxins.  Biochemistry.  31:12424-12430. 1992
• Effect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative study.  Comparative Biochemistry and Physiology Part C: Comparative Pharmacology.  101:433-436. 1992
• Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes).  Toxicon.  30:1299-1302. 1992
• Investigación y desarrollo en ciencias exactas y naturales.  Toxicon.  30:1099-1109. 1992
• Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom.  Archives of Biochemistry and Biophysics.  298:135-142. 1992
• Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies.  Toxicon.  30:239-245. 1992
• Skeletal muscle regeneration after myonecrosis induced by Bothrops asper (terciopelo) venom.  A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom.  120:169-190. 1992
• The efficacy of the bothropic/crotalic antivenom on the neuralization of the main Bothrops jararacussu venom activities | A EFICACIA DO ANTIVENENO BOTROPICO-CROTALICO NA NEUTRALIZACAO DAS PRINCIPAIS ATIVIDADES DO VENENO DE BOTHROPS JARARACUSSU.  Revista do Instituto de Medicina Tropical de Sao Paulo.  34:77-83. 1992
• Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo).  Blackburn, Nicholas B..  1992
• Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes.  Toxicon.  29:1273-1277. 1991
• DNase activity in Costa Rican crotaline snake venoms: Quantification of activity and identification of electrophoretic variants.  Toxicon.  29:1213-1224. 1991
• Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: A histochemical and immunocytochemical study.  International Journal of Experimental Pathology.  72:211-226. 1991
• Enlace al artículo.  Brazilian Journal of Medical and Biological Research.  24:701-710. 1991
• Quantitation by enzyme-immunoassay of antibodies against bothrops myotoxins in four commercially-available antivenoms.  Toxicon.  29:695-702. 1991
• Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu.  Blackburn, Nicholas B..  55:217-229. 1991
• The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities.  Biochimica et Biophysica Acta - Biomembranes.  1070:455-460. 1991
• Changes in myofibrillar components after skeletal muscle necrosis induced by a myotoxin isolated from the venom of the snake Bothrops asper.  Blackburn, Nicholas B..  52:25-36. 1990
• Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability.  Toxicon.  28:379-384. 1990
• International Journal of Renewable Energy & Biofuels.  Toxicon.  28:75-81. 1990
• Isolation of basic myotoxins from Bothrops Moojeni and Bothrops Atrox snake venoms.  Toxicon.  28:1137-1146. 1990
• Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica.  Toxicon.  28:419-426. 1990
• South American snake venom proteins antigenically related to Bothrops asper myotoxins..  Brazilian Journal of Medical and Biological Research.  23:427-435. 1990
• Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom.  Toxicon.  27:841-848. 1989
• Enlace al artículo.  Revista de Biología Tropical.  37:187-191. 1989
• Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica.  Toxicon.  27:735-745. 1989
• A new method for the detection of phospholipase A2 variants: Identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes.  Toxicon.  26:363-371. 1988
• An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica.  Toxicon.  26:411-413. 1988
• Anticoagulant effect of myotoxic phospholipase A2 isolated from the venom of the snake Bothrops asper (Viperidae)..  Revista de Biología Tropical.  36:563-565. 1988
• Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes.  Toxicon.  26:403-409. 1988
• Bothrops ophryomegas Bocourt (Serpentes: Viperidae) in Costa Rica: distribution, lepidosis, sexual variation and karyotype | Bothrops ophryomegas Bocourt (Serpentes: Viperidae) en Costa Rica: distribución, lepidosis, variación sexual y cariotipo..  Revista de Biología Tropical.  36:187-190. 1988
• El suero antiofídico polivalente producido en Costa Rica: Estabilidad y capacidad neutralizante.  Revista Costarricense de Ciencias Medicas.  9:155-169. 1988
• Karyotypes of Five Species of Coral Snakes (Micrurus).  Journal of Herpetology.  22:109-112. 1988
• Ability of a polyvalent antivenom to neutralize the venom of Lachesis Muta Melanocephala, a new Costa Rican subspecies of the bushmaster.  Toxicon.  25:713-720. 1987
• Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo).  Toxicon.  25:443-449. 1987
• Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms.  Toxicon.  25:947-955. 1987
• Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum.  Toxicon.  25:1244-1248. 1987
• Neutralization of toxic and enzyme activities of 4 venoms from snakes of Guatemala and Honduras by the polyvalent antivenin produced in Costa Rica | Neutralización de las actividades tóxicas y enzimáticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica..  Revista de Biología Tropical.  35:59-67. 1987
• Comparative study of the edema-forming activity of costa rican snake venoms and its neutralization by a polyvalent antivenom.  Comparative Biochemistry and Physiology Part C: Comparative Pharmacology.  85:171-175. 1986
• Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer.  Toxicon.  24:885-894. 1986
• Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice.  British Journal of Experimental Pathology.  67:1-12. 1986
• Pharmacological activities of a toxic phospholipase a isolated from the venom of the snake Bothrops Asper.  Comparative Biochemistry and Physiology Part C: Comparative Pharmacology.  84:159-164. 1986
• Neutralization of hyaluronidase and indirect hemolytic activities of Costa Rican snake venoms by a polyvalent antivenom.  Toxicon.  23:1015-1018. 1985
• Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom.  Toxicon.  23:887-893. 1985
• Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle.  Toxicon.  22:115-128. 1984
• Mechanism of action of myotoxins isolated from snake venoms | Mecanismo de acción de miotoxinas aisladas de venenos de serpientes..  Revista de Biología Tropical.  32:213-222. 1984
• Estudio comparativo de los venenos de serpiente Cascabel (Crotalus durissus durissus) de ejemplares adultos y recien nacidos.  Toxicon.  21:379-384. 1983
• Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species.  Toxicon.  21:777-783. 1983
• Proteolytic activity of snake venoms of Costa Rica on casein | La actividad proteolítica de los venenos de serpientes de Costa Rica sobre la caseína..  Revista de Biología Tropical.  31:37-40. 1983
• Cortés Cabrera, Alvaro.  Toxicon.  20:571-579. 1982
• Camacho Villegas, Tanya.  Toxicon.  19:493-500. 1981
• Estudio ultraestructural de la mionecrosis inducida en raton por el veneno de terciopelo (Bothrops asper) de Costa Rica.  Toxicon.  19:773-782. 1981
• Efectos proteolitico, hemorragico y mionecrotico de los venenos de serpientes costarricenses de los generos Bothrops, Crotalus y Lachesis.  Toxicon.  18:315-321. 1980
• Hemorrhagic and myonecrotic effects of snake bites in the American continent | El problema de los efectos hemorrágico y mionecrótico por mordeduras de serpiente en el continente Americano..  Boletin de la Oficina Sanitaria Panamericana.  89:149-158. 1980
• Mionecrosis, hemorragia y edema inducidos por el veneno de Bothrops asper en ratón blanco.  Toxicon.  18:603-610. 1980