publicaciones seleccionadas
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artículo académico
- An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action. Toxicon. 130:885-901. 2019
- Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: Comparative characterization and synergism between Asp49 and Lys49 variants. Toxicon. 168:113-121. 2019
- Correction: Widespread local chronic stressors in Caribbean coastal habitats. PLoS ONE. 13:e0192016. 2018
- Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: Functional profiles of hemolytic and non-hemolytic isoforms. Toxicology Letters. 286:39-47. 2018
- Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: Comparison of high- and low-molecular weight fractions. Toxicon. 51:373-380. 2017
- Anthodiscus chocoensis Prance, especie forestal en peligro crítico de extinción en Costa Rica. Protein and Peptide Letters. 16:53-69. 2017
- Arcobacter Isolation from Minced Beef Samples in Costa Rica. Journal of Food Protection. 80:775-778. 2017
- Long-term Variability of H$_2$CO Masers in Star-forming Regions. The Astrophysical Journal Supplement Series. 232:1-17. 2017
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Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A
2 myotoxins: Are there additional effector mechanisms involved?. PeerJ. 2014. 2017 - Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach. Journal of Proteomics. 151:204-213. 2017
- Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region. Toxicon. 45:807-815. 2016
- Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms. Toxicon. 42:307-312. 2015
- Detection ofBabesia caballiandTheileria equiin Blood from Equines from Four Indigenous Communities in Costa Rica. Veterinary Medicine International. 2015:1-6. 2015
- Application of the Second Law of Thermodynamics To Explain the Working of Toys. Journal of Chemical Education. 91:687-691. 2014
- Epidemiology of rapes in Costa Rica: Characterization of victims, perpetrators and circumstances surrounding forced intercourse. Forensic Science International. 242:204-209. 2014
- Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus. Biochimie. 107:376-384. 2014
- La bioética vista por un biólogo en el siglo XXI. CoRis. 10:7-13. 2014
- Unrecognized coral species diversity masks differences in functional ecology. Proceedings of the Royal Society B: Biological Sciencies. 281. 2014
- Venomous snakes of Costa Rica: Biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics. Journal of Proteomics. 105:323-339. 2014
- Integrated "omics" profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus. BMC Genomics. 2013
- Investigación y desarrollo en ciencias exactas y naturales. Toxicon. 64:60-69. 2013
- 210. Understanding the Preclinical Efficacy Profile of Antivenoms: From the Lethality Potency Assay to Antivenomics. Toxicon. 60:203. 2012
- Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia. Toxicon. 59:344-355. 2012
- Purification of IgG and albumin from human plasma by aqueous two phase system fractionation. Biotechnology Progress. 28:1005-1011. 2012
- Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses. Journal of Proteomics. 75:5628-5645. 2012
- Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica. Toxicon. 59:592-599. 2012
- Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights. Journal of Proteomics. 75:1675-1689. 2012
- Antivenoms for snakebite envenomings. Inflammation and Allergy - Drug Targets. 10:369-380. 2011
- Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom. Toxicon. 58:558-564. 2011
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Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A
2 homologue from the venom of Bothrops asper. Cell Biochemistry and Function. 29:365-370. 2011 - Profiling the venom gland transcriptomes of costa rican snakes by 454 pyrosequencing. BMC Genomics. 12. 2011
- Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management. Journal of Proteomics. 74:510-527. 2011
- Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae). Journal of Proteome Research. 10:1816-1827. 2011
- Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities. Investigación y desarrollo en ciencias exactas y naturales. 1:8-17. 2010
- Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain. Proceedings of the National Academy of Sciences of the United States of America. 107:14140-14145. 2010
- Erratum to Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment [Toxicon 54, 7, (2009), 1012-1028]. Toxicon. 55:1412-1413. 2010
- Snake venomics of bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: Different evolutionary solutions for the same trophic purpose. Journal of Proteome Research. 9:4234-4241. 2010
- Snake venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America. Journal of Proteome Research. 9:528-544. 2010
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Synthetic peptides derived from the C-Terminal region of Lys49 phospholipase A
2 homologues from viperidae snake venoms: Biomimetic activities and potential applications. Current Pharmaceutical Design. 16:3224-3230. 2010 - The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes. Toxicon. 55:590-596. 2010
- Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?. Toxicon. 55:166-170. 2010
- Vesículas liposomales estabilizadas con Quitosano: Estudio Electrocinético. Revista Iberoamericana de Polímeros. 11:46-57. 2010
- Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper. Toxicon. 54:949-957. 2009
- Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism. Journal of Proteomics. 73:57-78. 2009
- Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming. Journal of Proteomics. 72:165-182. 2009
- Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: Report of a workshop. Toxicon. 53:625-630. 2009
- Venoms, venomics, antivenomics. FEBS Letters. 583:1736-1743. 2009
- Enlace al artículo. Journal of Proteomics. 71:46-60. 2008
- Snake venomics and antivenomics of the arboreal neotropical pitvipers bothriechis lateralis and bothriechis schlegelii. Journal of Proteome Research. 7:2445-2457. 2008
- Snake venomics of the lesser antillean pit vipers bothrops caribbaeus and Bothrops lanceolatus: Correlation with toxicological activities and immunoreactivity of a heterologous antivenom. Journal of Proteome Research. 7:4396-4408. 2008
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Isolation, characterization and molecular cloning of AnMIP, a new α-type phospholipase A
2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 146:60-68. 2007 - Trends in snakebite envenomation therapy: Scientific, technological and public health considerations. Current Pharmaceutical Design. 13:2935-2950. 2007
- Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom. Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62:423-426. 2006
- Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms. Cell Biochemistry and Function. 23:307-313. 2005
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Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A
2 homologues are reduced, but not abolished, by a pH-induced dissociation. Toxicon. 46:291-296. 2005 - Crystallization of the Lys49 PLA 2 homologue, myotoxin II, from the venom of Atropoides nummifer. Biochimica et Biophysica Acta - Proteins and Proteomics. 1703:87-89. 2004
- Bailey, Stephen M.. Revista de Biología Tropical. 51:253-259. 2003
- Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2. Biochemical Pharmacology. 66:1993-2000. 2003
- Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: Isolation, molecular cloning and biological properties. Biochemical Journal. 346:631-639. 2003
- Hemostatic effects induced by Thalassophryne nattereri fish venom: A model of endothelium-mediated blood flow impairment. Toxicon. 40:1141-1147. 2002
- Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A2 homologue. Disturbance compensation on uncertain systems: feedforward control design for stable systems. 34:1268-1278. 2002
- Immunochemical properties of the N-terminal helix of myotoxin II, a lysine-49 phospholipase A2 from Bothrops asper snake venom. Toxicon. 39:879-887. 2001
- Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice. International Journal of Experimental Pathology. 82:55-64. 2001
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Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: Comparative toxicological characterization, isolation of a myotoxic phospholipase A
2 homologue and neutralization by two antivenoms. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology. 129:151-162. 2001 - Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue. Disturbance compensation on uncertain systems: feedforward control design for stable systems. 32:63-71. 2000
- Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu. Biochimie. 82:755-763. 2000
- Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from Bothrops moojeni (Caissaca) snake venom. Archives of Biochemistry and Biophysics. 373:7-15. 2000
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Characterization of a basic phospholipase A
2 -homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarara chica) from Argentina. Toxicon. 37:1735-1746. 1999 -
Comparative study of the cytolytic activity of myotoxic phospholipases A
2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro. Toxicon. 37:145-158. 1999 - Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom. Toxicon. 35:81-90. 1997
- Effects of bleeding in horses immunized with snake venoms for antivenom production. Revista de Biología Tropical. 45:1215-1221. 1997
- Isolation and characterization of a myotoxic phospholipase A(2) from the venom of the arboreal snake Bothriechis (Bothtops) schlegelii from Costa Rica. Archives of Biochemistry and Biophysics. 339:260-266. 1997