artículo académico

• Evaluation of serological assays to monitor antibody responses to single-dose HPV vaccines.  Vaccine.  38:5997-6006. 2020
• Antivenom against Vipera berus is effective against Macrovipera lebetina.  Toxicon.  159:S32. 2019
• Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.  Toxicon.  159:S17-S18. 2019
• Nephrotoxicity induced by the venom of Hypnale hypnale from Sri Lanka: Studies on isolated perfused rat kidney and renal tubular cell lines.  Toxicon.  165:40-46. 2019
• Phylovenomics of Daboia russelii across the indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka.  Journal of Proteomics.  207:103443. 2019
• Physical characteristics of nano-Hydroxyapatite Pickering-emulsions and their adjuvant activity on the antibody response towards the Bothros asper snake venom.  Materials Science and Engineering: C.  100:23-29. 2019
• Aportes del modelo de Yrjö Engeström al desarrollo teórico de la docencia universitaria.  Journal of Proteomics.  181:104-117. 2018
• Contributions of the snake venoms of Bothrops asper, Crotalus simus and Lachesis stenophrys to the paraspecificity of the Central American polyspecific antivenom (PoliVal-ICP).  Toxicon.  144:1-6. 2018
• Current technology for the industrial manufacture of snake antivenoms.  Toxicon.  151:63-73. 2018
• Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom.  Toxicon.  10:380-781. 2018
• Effect of exposition to chlorpyrifos upon plasmatic cholinesterases, hematology and blood biochemistry values in Bothrops asper (Serpentes: Viperidae).  Chemosphere.  205:209-214. 2018
• Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A2: Role of negatively charged phospholipids as potential membrane binding sites.  Archives of Biochemistry and Biophysics.  148:56-64. 2018
• Revision of the main drivers and variability of Central America Climate and seasonal forecast systems.  Revista de Biología Tropical.  66:S153-S175. 2018
• Robust PI/PID controllers for load disturbance based on direct synthesis.  ISA Transactions.  59:158-162. 2018
• Active immunization of cattle with a bothropic toxoid does not abrogate envenomation by Bothrops asper venom, but increases the likelihood of survival.  Biologicals.  46:1-5. 2017
• An improved technique for the assessment of venom-induced haemorrhage in a murine model.  Toxicon.  139:87-93. 2017
• Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus).  Toxicon.  127:106-111. 2017
• Cross-reactivity and cross-immunomodulation between venoms of the snakes Bothrops asper , Crotalus simus and Lachesis stenophrys , and its effect in the production of polyspecific antivenom for Central America.  Toxicon.  138:43-48. 2017
• Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.  Biomedicine & Pharmacotherapy.  90:740-743. 2017
• Expanding the neutralization scope of the EchiTAb-plus-ICP antivenom to include venoms of elapids from Southern Africa.  Toxicon.  125:59-64. 2017
• Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol.  Toxicon.  133:123-126. 2017
• Physicochemical characterization of commercial freeze-dried snake antivenoms.  Toxicon.  126:32-37. 2017
• Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead.  Toxins.  9:163. 2017
• Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus).  Journal of Proteomics.  158:62-72. 2017
• Snakebite envenoming.  Nature Reviews Disease Primers.  3. 2017
• A polyspecific antivenom for Sri Lanka: First to include Hypnale.  Toxicon.  117:103. 2016
• Bothrops asper envenoming in cattle: Clinical features and management using equine-derived whole IgG antivenom.  Revista de Biologia Marina y Oceanografia.  207:160-163. 2016
• Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom.  Toxicon.  120:1-8. 2016
• Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom.  Toxicon.  122:152-159. 2016
• Improved PID controller tuning rules for performance degradation/robustness increase trade-off.  Electrical Engineering.  98:233-243. 2016
• Journal of Clinical Immunology.  Revista de Biología Tropical.  65. 2016
• Journal of Herpetology.  Toxicon.  119:171-179. 2016
• Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab')2 and whole IgG antivenoms.  Toxicology Letters.  241:175-183. 2016
• Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms.  Toxicon.  108:80-83. 2015
• Assessing endotoxins in equine-derived snake antivenoms: Comparison of the USP pyrogen test and the Limulus Amoebocyte Lysate assay (LAL).  Toxicon.  105:13-18. 2015
• Human plasma-derived immunoglobulin G fractionated by an aqueous two-phase system, caprylic acid precipitation, and membrane chromatography has a high purity level and is free of detectable in vitro thrombogenic activity.  Vox Sanguinis.  108:169-177. 2015
• Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom.  Toxicon.  103:99-105. 2015
• Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step.  Biologicals.  43:37-46. 2015
• A Comparison of four Methods to Evaluate the Butterfly Abundance. Using a Tropical Community.  Journal of Immunotoxicology.  11:241-243. 2014
• Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.  American Journal of Tropical Medicine and Hygiene.  91:887-894. 2014
• Epidemiology of rapes in Costa Rica: Characterization of victims, perpetrators and circumstances surrounding forced intercourse.  Forensic Science International.  242:204-209. 2014
• Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test.  Toxicon.  90:56-63. 2014
• Fructose 1-phosphate is the one and only physiological effector of the Cra (FruR) regulator of Pseudomonas putida.  FEBS Open Bio.  4:377-386. 2014
• Industrial Production and Quality Control of Snake Antivenoms.  Toxinology.  24:1-22. 2014
• Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica.  Toxicon.  88:34-37. 2014
• Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics.  Toxicon.  69:168-179. 2013
• Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods.  Biologicals.  41:93-97. 2013
• Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms.  Toxicon.  76:63-76. 2013
• Role of the animal model on the pharmacokinetics of equine-derived antivenoms.  Toxicon.  70:9-14. 2013
• 210. Understanding the Preclinical Efficacy Profile of Antivenoms: From the Lethality Potency Assay to Antivenomics.  Toxicon.  60:203. 2012
• Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity.  Journal of Proteomics.  75:2128-2140. 2012
• La situación de los antivenenos liofilizados en América Latina: Aspectos tecnológicos y de salud pública.  Gazeta Médica da Bahia.  82:106-109. 2012
• Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation.  Biologicals.  40:129-133. 2012
• Purification of IgG and albumin from human plasma by aqueous two phase system fractionation.  Biotechnology Progress.  28:1005-1011. 2012
• Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses.  Journal of Proteomics.  75:5628-5645. 2012
• Streptococcus pneumoniae serotypes isolated from the middle ear fluid of Costa Rican children following introduction of the heptavalent pneumococcal conjugate vaccine into a limited population.  Vaccine.  30:3857-3861. 2012
• Antivenoms for snakebite envenomings.  Inflammation and Allergy - Drug Targets.  10:369-380. 2011
• Antivenoms for the treatment of snakebite envenomings: The road ahead.  Biologicals.  39:129-142. 2011
• Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms.  Toxicon.  57:237-243. 2011
• Immune response towards snake venoms.  Inflammation and Allergy - Drug Targets.  10:381-398. 2011
• Preclinical evaluation of caprylic acid-fractionated igg antivenom for the treatment of taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea.  PLoS Neglected Tropical Diseases.  5. 2011
• Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.  American Journal of Tropical Medicine and Hygiene.  82:1194-1201. 2010
• Erratum to Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment [Toxicon 54, 7, (2009), 1012-1028].  Toxicon.  55:1412-1413. 2010
• Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows.  Biologicals.  38:664-669. 2010
• Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP (R)) for the treatment of viper envenoming in sub-Saharan Africa.  Toxicon.  55:369-374. 2010
• Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms.  Toxicon.  56:980-989. 2010
• Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom.  Biologicals.  38:577-585. 2010
• Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom.  Biologicals.  37:306-312. 2009
• Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom.  Cuadernos de Investigación UNED (UNED Research Journal).  1:233-244. 2009
• Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production.  Biologicals.  37:230-234. 2009
• Enlace al artículo.  Journal of Proteome Research.  9:564-577. 2009
• Investigación y desarrollo en ingenierías y tecnologías.  Toxicon.  54:1012-1028. 2009
• Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  102:1115-1119. 2008
• Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations.  Biologicals.  35:5-11. 2007
• Trends in snakebite envenomation therapy: Scientific, technological and public health considerations.  Current Pharmaceutical Design.  13:2935-2950. 2007
• Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  100:1173-1182. 2006
• Immunoenzimatic detection of the clostridium tetani bacterial toxin: An alternative to mice bioassays.  Revista de Biología Tropical.  54:253-256. 2006
• Anticomplementary activity of equine whole IgG antivenoms: Comparison of three fractionation protocols.  Toxicon.  45:123-128. 2005
• Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: An alternative to the antivenom crisis in Africa.  Transactions of the Royal Society of Tropical Medicine and Hygiene.  99:468-475. 2005
• Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.  Clinical Pharmacokinetics.  42:721-741. 2003
• Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation.  Biologicals.  30:143-151. 2002
• Comparison between IgG and F(ab′)2 polyvalent antivenoms: Neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions.  Toxicon.  39:793-801. 2001
• Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: Effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.  American Journal of Tropical Medicine and Hygiene.  63:313-319. 2000
• A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: Correlation between safety and biochemical characteristics of antivenoms.  Toxicon.  37:895-908. 1999
• Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.  American Journal of Tropical Medicine and Hygiene.  61:266-271. 1999
• Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production.  Toxicon.  36:321-331. 1998
• Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom.  Toxicon.  36:1529-1538. 1998
• Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by bothrops asper (terciopelo) snake venom.  Toxicon.  35:1627-1637. 1997