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Snakebite envenoming in French Guiana: Assessment of the preclinical efficacy against the venom of Bothrops atrox of two polyspecific antivenoms. 173:1-4. 2020
A functional role for snake envenomation wound exudate in local and systemically observed pathophysiology. 158:S1. 2019
An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action. 130:885-901. 2019
Antivenom against Vipera berus is effective against Macrovipera lebetina. 159:S32. 2019
Cocktails of human monoclonal IgG antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba venom in vivo. 159:S5-S6. 2019
Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model. 159:S17-S18. 2019
Escuela de Educación Física y Deportes, UCR. 159:61-62. 2019
Harnessing human monoclonal antibodies for neutralisation of dendrotoxins in a murine model. 159:S14. 2019
Harnessing phage display technology for discovery of human IgGs targeting clinically relevant toxins from the venom of the Central American coral snake (Micrurus nigrocinctus). 158:S45. 2019
Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: Comparative characterization and synergism between Asp49 and Lys49 variants. 168:113-121. 2019
Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu. 18:1063-1069. 2019
Monoclonal human IgGs capable of neutralizing elapid neurotoxins in vivo. 158:S44. 2019
Nephrotoxicity induced by the venom of Hypnale hypnale from Sri Lanka: Studies on isolated perfused rat kidney and renal tubular cell lines. 165:40-46. 2019
Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2. 157:1-7. 2019
Structural analysis of a myotoxin-antimyotoxin complex by cross-linking, mass spectrometry, and bioinformatics. 158:S29-S30. 2019
Three-finger toxins from the venom of Micrurus tschudii tschudii (desert coral snake): Isolation and characterization of tschuditoxin-I. 167:144-151. 2019
Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): Composition, biochemical activities and in vivo toxicity for potential prey. 171:7-19. 2019
A myotoxic Lys49 phospholipase A 2 -homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina. 148:143-148. 2018
Analgesic effect of morphine and tramadol in standard toxicity assays in mice injected with venom of the snake Bothrops asper. 154:35-41. 2018
Antivenoms: Life-saving drugs for envenomings by animal bites and stings. 150:11-12. 2018
Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis. 10:115-118. 2018
Contributions of the snake venoms of Bothrops asper, Crotalus simus and Lachesis stenophrys to the paraspecificity of the Central American polyspecific antivenom (PoliVal-ICP). 144:1-6. 2018
Current technology for the industrial manufacture of snake antivenoms. 151:63-73. 2018
Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom. 10:380-781. 2018
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: Pharmacological mediation and molecular determinants. 41:667-678. 2018
Isolation from a polyvalent antivenom of antibodies to a myotoxin in Bothrops asper snake venom. 23:807-813. 2018
Light Emitting Diode (LED) therapy reduces local pathological changes induced by Bothrops asper snake venom. 152:95-102. 2018
Olivo, Renata do A.. 146:87-90. 2018
Preclinical assessment of the neutralizing efficacy of antivenoms in Latin America and the Caribbean: A review. 146:138-150. 2018
Preclinical evaluation of the neutralizing ability of a monospecific antivenom for the treatment of envenomings by Bothrops lanceolatus in Martinique. 148:50-55. 2018
Pros and cons of different therapeutic antibody formats for recombinant antivenom development. 146:151-175. 2018
Proteomic studies on Micrurus (coral snakes) venom reveal a dichotomy of phenotypes. 150:319-320. 2018
Robust PI/PID controllers for load disturbance based on direct synthesis. 59:158-162. 2018
Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms. 148:123-131. 2018
Venom gland transcriptomics and microRNA profiling of juvenile and adult yellow-bellied sea snake, Hydrophis platurus, from Playa del Coco (Guanacaste, Costa Rica). 153:96-105. 2018
Pitfalls to avoid when using phage display for snake toxins. 121:79-89. 2017
Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: Comparison of high- and low-molecular weight fractions. 51:373-380. 2017
An improved technique for the assessment of venom-induced haemorrhage in a murine model. 139:87-93. 2017
Assessing survival of wild-caught snakes in open venom production systems. 138:49-52. 2017
Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles). 137:158-167. 2017
Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus). 127:106-111. 2017
Cross-reactivity and cross-immunomodulation between venoms of the snakes Bothrops asper , Crotalus simus and Lachesis stenophrys , and its effect in the production of polyspecific antivenom for Central America. 138:43-48. 2017
Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis. 107:187-196. 2017
Expanding the neutralization scope of the EchiTAb-plus-ICP antivenom to include venoms of elapids from Southern Africa. 125:59-64. 2017
Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol. 133:123-126. 2017
Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom. 132:55-61. 2017
High-density peptide microarray exploration of the antibody response in a rabbit immunized with a neurotoxic venom fraction. 138:151-158. 2017
Identification of B cell recognized linear epitopes in a snake venom serine proteinase from the central American bushmaster Lachesis stenophrys. 140:72-82. 2017
Peptidomimetic hydroxamate metalloproteinase inhibitors abrogate local and systemic toxicity induced by Echis ocellatus (saw-scaled) snake venom. 135:40-49. 2017
Physicochemical characterization of commercial freeze-dried snake antivenoms. 126:32-37. 2017
Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii. 119:289-298. 2016
A polyspecific antivenom for Sri Lanka: First to include Hypnale. 117:103. 2016
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region. 45:807-815. 2016
De León Castrejón, Tirza. 109:51-62. 2016
Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom. 120:1-8. 2016
Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom. 122:152-159. 2016
Journal of Herpetology. 119:171-179. 2016
Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics. 119:280-288. 2016
Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses. 122:7-25. 2016
Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms. 108:80-83. 2015
Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins. 99:23-35. 2015
A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line. 45:651-660. 2015
A bright future for integrative venomics. 107:159-162. 2015
Assessing endotoxins in equine-derived snake antivenoms: Comparison of the USP pyrogen test and the Limulus Amoebocyte Lysate assay (LAL). 105:13-18. 2015
Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms. 42:307-312. 2015
Efectos locales inducidos por el veneno de la serpiente coral Micrurus nigrocinctus en ratón blanco. 18:633-639. 2015
Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria. 106:97-107. 2015
First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis. 93:144-154. 2015
Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom. 103:99-105. 2015
Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score. 104:43-45. 2015
Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids. 107:217-233. 2015
The multigene families of actinoporins (Part I): Isoforms and genetic structure.. 103:176-187. 2015
Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: Identification of directly hemolytic phospholipases A2. 90:26-35. 2014
Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia. 90:15-25. 2014
A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom. 87:81-91. 2014
An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes. 30:815-823. 2014
Enlace al artículo. 46:806-813. 2014
Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test. 90:56-63. 2014
Production in E. coli, folding, purification and characterization of notexin with wild type sequence and with N-terminal and catalityc site mutations.. 88:11-20. 2014
The analgesics morphine and tramadol do not alter the acute toxicity induced by Bothrops asper snake venom in mice. 81:54-57. 2014
The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay. 93:41-50. 2014
Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica. 88:34-37. 2014
Amino acid sequence and biological characterization of BlatPLA2, a non-toxic acidic phospholipase A2 from the venom of the arboreal snake Bothriechis lateralis from Costa Rica. 73:71-80. 2013
Antivenom for snakebite envenoming in Sri Lanka: The need for geographically specific antivenom and improved efficacy. 69:90-97. 2013
Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics. 69:168-179. 2013
Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom. 63:32-43. 2013
Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico. 71:84-95. 2013
Enlace al artículo. 33:1387-1391. 2013
Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P–I metalloproteinase from Bothrops asper snake venom: Insights from docking and molecular modeling. 71:41-48. 2013
Investigación y desarrollo en ciencias exactas y naturales. 64:60-69. 2013
Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms. 76:63-76. 2013
Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins. 18:27-39. 2013
Role of the animal model on the pharmacokinetics of equine-derived antivenoms. 70:9-14. 2013
Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model. 63:19-31. 2013
160. Role of SVMPs, Matrikines and TLR4 in Snake Venom Induced Edema and Inflammation. 60:177. 2012
192. Action of Venom Metalloproteinases on Basement Membranes: Pathogenesis of Hemorrhage and Blistering in Snakebite Envenomings. 60:194-194. 2012
210. Understanding the Preclinical Efficacy Profile of Antivenoms: From the Lethality Potency Assay to Antivenomics. 60:203. 2012
222. Molecular Mechanisms Involved in PGE2 Release Induced by the Snake Venom Metalloproteinase BaP1 in Synoviocytes. 60:209-209. 2012
Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia. 59:344-355. 2012
Identification of linear B-cell epitopes on myotoxin II, a Lys49 phospholipase A2 homologue from Bothrops asper snake venom. 60:782-790. 2012
Improving antivenom availability and accessibility: Science, technology, and beyond. 60:676-687. 2012
Isolation and biochemical, functional and structural characterization of a novel l-amino acid oxidase from Lachesis muta snake venom. 60:1263-1276. 2012
Mipartoxin-I, a novel three-finger toxin, is the major neurotoxic component in the venom of the redtail coral snake Micrurus mipartitus (Elapidae). 60:851-863. 2012
Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols. 60:688-699. 2012
Snake venom Lys49 myotoxins: From phospholipases A 2 to non-enzymatic membrane disruptors. 60:520-530. 2012
Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica. 59:592-599. 2012
Standardization of assays for testing the neutralizing ability of antivenoms. 28:1127-1129. 2012
The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: An intravital and electron microscopic study. 32:41-55. 2012
A phospholipase A2 from Bothrops asper snake venom activates neutrophils in culture: Expression of cyclooxygenase-2 and PGE2 biosynthesis. 57:288-296. 2011
Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom. 58:558-564. 2011
Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms. 57:237-243. 2011
Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica. 38:1429-1441. 2011
Acute physiopathological effects of honeybee (Apis mellifera) envenoming by subcutaneous route in a mouse model. 56:1007-1017. 2010
Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: Effects on enzymatic and pharmacological properties. 35:241-252. 2010
Consultorías en ciencias de la salud. 55:642-645. 2010
Docencia universitaria en pregrado en ingenierías y tecnologías. 56:1059-1065. 2010
Erratum to Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment [Toxicon 54, 7, (2009), 1012-1028]. 55:1412-1413. 2010
Isolation and biological characterization of Batx-I, a weak hemorrhagic and fibrinogenolytic PI metalloproteinase from Colombian Bothrops atrox venom. 56:936-943. 2010
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP (R)) for the treatment of viper envenoming in sub-Saharan Africa. 55:369-374. 2010
Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms. 56:980-989. 2010
Snakebite envenoming from a global perspective: Towards an integrated approach. 56:1223-1235. 2010
The C-terminal region of a Lys49 myotoxin mediates Ca²⁺ influx in C2C12 myotubes. 55:590-596. 2010
Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?. 55:166-170. 2010
Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper. 54:949-957. 2009
Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom. 1:233-244. 2009
Experimental pathology of local tissue damage induced by Bothrops asper snake venom. 54:958-975. 2009
Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom. 54:976-987. 2009
Inflammation induced by Bothrops asper venom. 54:988-997. 2009
Investigación y desarrollo en ingenierías y tecnologías. 54:1012-1028. 2009
Natural history of the terciopelo Bothrops asper (Serpentes: Viperidae) in Costa Rica. 54:904-922. 2009
Phenotypic differences in a cryptic predator: Factors influencing morphological variation in the terciopelo Bothrops asper (Garman, 1884; Serpentes: Viperidae). 54:923-937. 2009
Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature. 53:609-615. 2009
Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: Report of a workshop. 53:625-630. 2009
Studies on the venom proteome of Bothrops asper: Perspectives and applications. 54:938-948. 2009
A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo). 27:589-596. 2008
Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom. 52:754-759. 2008
Immunization with cDNA of a novel P-III type metalloproteinase from the rattlesnake Crotalus durissus durissus elicits antibodies which neutralize 69% of the hemorrhage induced by the whole venom. 52:302-308. 2008
Matchar, David B.. 52:428-439. 2008
Mortality due to snakebite envenomation in Costa Rica (1993-2006). 52:530-533. 2008
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: Comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue. 51:80-92. 2008
Cytotoxicity of Lachesis muta muta snake (bushmaster) venom and its purified basic phospholipase A2 (LmTX-I) in cultured cells. 49:678-692. 2007
Dissociation of enzymatic and toxic activities by the use of antibodies. 28:1245-1246. 2007
El centenario del nacimiento de Clodomiro Picado T. y el retorno del Mutacionismo. 35:1-4. 2007
Role of cyclooxygenases in oedema-forming activity of bothropic venoms. 49:670-677. 2007
Strengthening antivenom production in Central and South American public laboratories: Report of a workshop. 49:30-35. 2007
Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A 2 homologue on a lymphoblastoid cell line. 47:75-86. 2006
Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: Leukocyte recruitment and release of cytokines. 47:549-559. 2006
Pharmacokinetics of whole IgG equine antivenom: Comparison between normal and envenomed rabbits. 48:255-263. 2006
Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A2. 46:523-532. 2005
Anticomplementary activity of equine whole IgG antivenoms: Comparison of three fractionation protocols. 45:123-128. 2005
Hemorrhage induced by snake venom metalloproteinases: Biochemical and biophysical mechanisms involved in microvessel damage. 45:997-1011. 2005
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A 2 isolated from Bothrops asper snake venom: Role of catalytic activity. 45:335-346. 2005
Journal of Pharmaceutical Analysis. 45:171-178. 2005
Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A 2 homologues are reduced, but not abolished, by a pH-induced dissociation. 46:291-296. 2005
Bothrops asper metalloproteinase BaP1 is inhibited by α 2-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy. 43:213-217. 2004
Effect of a recombinant Lys49PLA2 myotoxin and Lys49PLA 2-derived synthetic peptides from Agkistrodon species on membrane permeability to water. 44:157-159. 2004
Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: Understanding the role of metalloproteinases in envenomation. 43:417-424. 2004
Membrane independent activation of fibroblast proMMP-2 by snake venom: Novel roles for venom proteinases. 44:749-764. 2004
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox. 44:91-101. 2004
A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa. 42:35-41. 2003
Benavides, Yeison. 42:801-808. 2003
Enlace al artículo. 42:405-411. 2003
Guest editor's foreword. 42:825-826. 2003
Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: Comparison between Fab and IgG. 41:237-244. 2003
Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes. 41:851-860. 2003
Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene. 42:979-986. 2003
Skeletal muscle degeneration induced by venom phospholipases A 2: Insights into the mechanisms of local and systemic myotoxicity. 42:915-931. 2003
Snakebite envenomation in Costa Rica: a revision of incidence in the decade 1990–2000. 41:19-22. 2003
Hemostatic effects induced by Thalassophryne nattereri fish venom: A model of endothelium-mediated blood flow impairment. 40:1141-1147. 2002
Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo. 39:1505-1513. 2001
Comparison between IgG and F(ab′)2 polyvalent antivenoms: Neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions. 39:793-801. 2001
Identification of the myotoxic site of the Lys49 phospholipase A2 from Agkistrodon piscivorus piscivorus snake venom: Synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities. 39:1587-1594. 2001
Immunochemical properties of the N-terminal helix of myotoxin II, a lysine-49 phospholipase A2 from Bothrops asper snake venom. 39:879-887. 2001
Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae). 39:1863-1869. 2001
Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom. 39:1173-1181. 2001
Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica. 38:633-644. 2000
Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms. 38:1253-1266. 2000
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper. 38:63-77. 2000
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: Correlation between safety and biochemical characteristics of antivenoms. 37:895-908. 1999
Characterization of a basic phospholipase A2-homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarara chica) from Argentina. 37:1735-1746. 1999
Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom. 37:1297-1312. 1999
Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro. 37:145-158. 1999
Inhibition of the myotoxic activity of Bothrops asper myotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129. 37:683-687. 1999
Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothirops snake venoms. 37:551-557. 1999
Structure of a Lys49-Phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper). 37:371-384. 1999
Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica. 36:2021-2027. 1998
Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production. 36:321-331. 1998
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom. 36:1529-1538. 1998
Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo). 36:1861-1869. 1998
A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus. 35:573-581. 1997
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom. 35:81-90. 1997
Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by bothrops asper (terciopelo) snake venom. 35:1627-1637. 1997
Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture. 35:865-877. 1997
Snakebite mortality in Costa Rica. 35:1639-1643. 1997
Universidad de París VII Denis Diderot, Francia. 35:1605-1616. 1997
Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from Micrurus nigrocinctus nigrocinctus (coral snake) venom. 34:369-380. 1996
Biochemical and biological characterization of Ecudadorian pitviper venoms (genera Bothriechis, bothriopsis, bothrops and Lachesis). 34:714-717. 1996
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice. 34:567-577. 1996
Similar effectiveness of Fab and F(ab')2 antivenoms in the neutralization of hemorrhagic activity of vipera Berus snake venom in mice. 34:1197-1202. 1996
Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia). 33:809-815. 1995
Evaluacion de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica. 33:1242-1247. 1995
Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper. 33:1103-1106. 1995
Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo). 33:19-29. 1995
Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice. 33:31-39. 1995
Phospholipase A2 myotoxins from Bothrops snake venoms. 33:1405-1424. 1995
The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom. 33:679-689. 1995
Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro. 32:505-510. 1994
Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom. 32:1359-1369. 1994
Caprylic acid fractionation of hyperimmune horse plasma: Description of a simple procedure for antivenom production. 32:351-363. 1994
Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro. 32:1689-1695. 1994
Electrophoretic and immunochemical studies of Micrurus snake venoms. 32:713-723. 1994
Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies. 32:695-712. 1994
Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels. 32:977-987. 1994
Biological and biochemical activities of Vipera berus (European viper) venom. 31:743-753. 1993
Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops Asper (terciopelo) and Bothrops Nummifer (jumping viper). 31:1061-1064. 1993
Effects of Bothrops asper (terciopelo) myotoxin III, a basic phospholipase A2, on liposomes and mouse gastrocnemius muscle. 31:217-222. 1993
Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper. 31:1137-1150. 1993
Turbidity of hyperimmune equine antivenom: The role of phenol and serum lipoproteins. 31:61-66. 1993
p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities. 31:1202-1206. 1993
Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes). 30:1299-1302. 1992
Investigación y desarrollo en ciencias exactas y naturales. 30:1099-1109. 1992
Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies. 30:239-245. 1992
Skeletal muscle regeneration after myonecrosis induced by Bothrops asper (terciopelo) venom. 120:169-190. 1992
Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes. 29:1273-1277. 1991
DNase activity in Costa Rican crotaline snake venoms: Quantification of activity and identification of electrophoretic variants. 29:1213-1224. 1991
Quantitation by enzyme-immunoassay of antibodies against bothrops myotoxins in four commercially-available antivenoms. 29:695-702. 1991
Effect of storage temperature on the stability of the liquid polyvalent antivenom produced in Costa Rica. 28:101-105. 1990
Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability. 28:379-384. 1990
International Journal of Renewable Energy & Biofuels. 28:75-81. 1990
Isolation of basic myotoxins from Bothrops Moojeni and Bothrops Atrox snake venoms. 28:1137-1146. 1990
Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica. 28:419-426. 1990
Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom. 27:841-848. 1989
Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice. 27:1085-1093. 1989
Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica. 27:735-745. 1989
A new method for the detection of phospholipase A2 variants: Identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes. 26:363-371. 1988
An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica. 26:411-413. 1988
Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes. 26:403-409. 1988
Daniels, Stephen R.. 26:675-689. 1988
Ability of a polyvalent antivenom to neutralize the venom of Lachesis Muta Melanocephala, a new Costa Rican subspecies of the bushmaster. 25:713-720. 1987
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo). 25:443-449. 1987
Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms. 25:947-955. 1987
Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum. 25:1244-1248. 1987
Immunohistochemical demonstration of the binding of Bothrops asper myotoxin to skeletal muscle sarcolemma. 25:574-577. 1987
Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer. 24:885-894. 1986
Edema-forming activity of bushmaster (Lachesis muta stenophrys) and Central American rattlesnake (Crotalus durissus durissus) venoms and neutralization by a polyvalent antivenom. 23:173-176. 1985
Neutralization of hyaluronidase and indirect hemolytic activities of Costa Rican snake venoms by a polyvalent antivenom. 23:1015-1018. 1985
Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom. 23:887-893. 1985
Estudio ultraestructural de las alteractiones locales inducidas en raton blanco por el veneno de Bothrops picadoi de Costa Rica. 22:301-305. 1984
Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle. 22:115-128. 1984
Estudio comparativo de los venenos de serpiente Cascabel (Crotalus durissus durissus) de ejemplares adultos y recien nacidos. 21:379-384. 1983
Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species. 21:777-783. 1983
Cortés Cabrera, Alvaro. 20:571-579. 1982
Estudio de la capacidad ofiofaga y la resistencia de la zopilota (Clelia clelia, Colubridae) de Costa Rica a los venenos de serpiente. 20:936-939. 1982
Camacho Villegas, Tanya. 19:493-500. 1981
Estudio ultraestructural de la mionecrosis inducida en raton por el veneno de terciopelo (Bothrops asper) de Costa Rica. 19:773-782. 1981
Efectos proteolitico, hemorragico y mionecrotico de los venenos de serpientes costarricenses de los generos Bothrops, Crotalus y Lachesis. 18:315-321. 1980
Mionecrosis, hemorragia y edema inducidos por el veneno de Bothrops asper en ratón blanco. 18:603-610. 1980

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