Abstracto
- In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the transcription factor NF-κB as molecular target. NF-κB is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-κB DNA binding was inhibited at micromolar concentrations by all Sls.