artículo académico

• Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro.  Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology.  217:54-67. 2019
• Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): Composition, biochemical activities and in vivo toxicity for potential prey.  Toxicon.  171:7-19. 2019
• Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A2: Role of negatively charged phospholipids as potential membrane binding sites.  Archives of Biochemistry and Biophysics.  148:56-64. 2018
• Robust PI/PID controllers for load disturbance based on direct synthesis.  ISA Transactions.  59:158-162. 2018
• Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles).  Toxicon.  137:158-167. 2017
• Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: Are there additional effector mechanisms involved?.  PeerJ.  2014. 2017
• Giglio, José Roberto.  Cuadernos de Investigación UNED (UNED Research Journal).  8:55-59. 2016
• A Lys49 phospholipase A2 homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line.  Toxicon.  45:651-660. 2015
• Rapid Changes of Body Weight after a Headstand: A Metrological Analysis.  PLoS ONE.  10:e0124764. 2015
• Estudio de validación preclínica del uso tradicional anti-tumoral de uncaria tomentosa (uña de gato).  Revista Médica de la Universidad de Costa Rica.  6:24-31. 2012
• Chemical Analysis of Essential Oils from Ocotea gomezii W.C. Burger and Ocotea morae Gómez-Laur. (Lauraceae) Collected at "Reserva Biológica Alberto M. Brenes" in Costa Rica and their Cytotoxic Activity on Tumor Cell Lines.  Journal of the Brazilian Chemical Society.  22:741-745. 2011
• Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure−Antimalarial Activity Relationships and Mechanistic Studies.  Journal of Medical Chemistry.  54:734-750. 2011
• Leaf Essential Oil of Manekia naranjoana (Piperaceae) from Costa Rica and its Cytotoxic Activity.  Natural Product Communications.  6:145-148. 2011
• Cell death induced by Bothrops asper snake venom metalloproteinase on endothelial and other cell lines.  Blackburn, Nicholas B..  88:424-432. 2010
• Chemical Composition of Aiouea costaricensis (Lauraceae) Essential Oils from Costa Rica and their Cytotoxic Activity on Cell Lines.  Journal of Essential Oil Research.  22:524-529. 2010
• Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: Effects on enzymatic and pharmacological properties.  Toxicon.  35:241-252. 2010
• Composición de carotenoides y actividad antioxidante del mesocarpo crudo y hervido del fruto de seis variedades de Bactris gasipaes/ Carotenoid composition and antioxidant activity of the raw and boiled fruit mesocarp of six varieties of Bactris gasipaes.  Archivos latinoamericanos de nutrición.  60:99-104. 2010
• Experimental pathology of local tissue damage induced by Bothrops asper snake venom.  Toxicon.  54:958-975. 2009
• Extracto y fracción alcaloidal de Annona muricata con actividad de tipo ansiolítica en ratones./ Anxiolytic-like effect of the extract and alkaloid fraction from Annona muricata in mice.  Revista Colombiana de Ciencias Químico - Farmaceúticas.  38:105-109. 2009
• Volatile compounds of Nectandra salicina (lauraceae) from Costa Rica and their cytotoxic activity on cell lines.  Química Nova.  32:417-420. 2009
• Chemical composition of Schinus molle essential oil and its cytotoxic activity on tumour cell lines.  Natural Product Research.  22:1521-1534. 2008
• Antipyretic effect of the aqueous extract obtained from leaves of Neurolaena lobata (Asteraceae) on a pyretic model induced by brewer's yeast.  Revista Médica de la Universidad de Costa Rica.  1:20-27. 2007
• Characterization of cell death events induced by anti-neoplastic drugs cisplatin, paclitaxel and 5-fluorouracil on human hepatoma cell lines: Possible mechanisms of cell resistance.  Biomedicine & Pharmacotherapy.  61:347-355. 2007
• Cytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell lines.  International Journal of Pharmaceutics.  325:108-115. 2006
• Apoptotic events induced by naturally occurring retinoids ATRA and 13-cis retinoic acid on human hepatoma cell lines Hep3B and HepG2.  Cancer Letters.  229:271-281. 2005
• Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells.  Journal of Cellular Biochemistry.  94:520-528. 2005
• Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper.  Mediators of Inflammation.  11:121-128. 2002
• Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.  Biochimie.  82:755-763. 2000
• Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani.  Archives of Biochemistry and Biophysics.  366:177-182. 1999
• Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani.  Laboratorio de Plasma para Energía de Fusión y Aplicaciones, TEC.  1384:204-208. 1998
• Crystallization and preliminary X-ray diffraction analysis of a Lys49-PLA 2 homologue from Cerrophidion Godmani venom.  Protein and Peptide Letters.  36:121-126. 1998
• Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo).  Toxicon.  33:19-29. 1995
• Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom.  Natural Toxins.  3:26-31. 1995
• Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect.  Archives of Biochemistry and Biophysics.  312:336-339. 1994
• p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities.  Toxicon.  31:1202-1206. 1993
• Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom.  Archives of Biochemistry and Biophysics.  298:135-142. 1992
• Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies.  Toxicon.  30:239-245. 1992
• The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities.  Biochimica et Biophysica Acta - Biomembranes.  1070:455-460. 1991