artículo académico

• Comparison of immediate colposcopy, repeat conventional cytology and high‐risk human papillomavirus testing for the clinical management of atypical squamous cells of undetermined significance cytology in routine health services of Medellin, Colombia: The ASCUS‐COL trial.  International Journal of Cancer.  614. 2020
• A functional role for snake envenomation wound exudate in local and systemically observed pathophysiology.  Toxicon.  158:S1. 2019
• Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening.  Toxins.  11:170. 2019
• Proteomic Analysis of Human Blister Fluids Following Envenomation by Three Snake Species in India: Differential Markers for Venom Mechanisms of Action.  Toxins.  11:246. 2019
• Site mutation of residues in a loop surrounding the active site of a P[sbnd]I snake venom metalloproteinase abrogates its hemorrhagic activity.  Biochemical and Biophysical Research Communications.  512:859-863. 2019
• Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis.  Pharmaceutical and Pharmacological Letters.  10:115-118. 2018
• In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF 165 neutralization.  Oncotarget.  9:28016-28029. 2018
• Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases.  Journal of Proteomics.  317:1781-1794. 2018
• Metalloproteinases in disease: identification of biomarkers of tissue damage through proteomics.  Expert Review of Proteomics.  15:967-982. 2018
• Systemic vascular leakage induced in mice by Russell’s viper venom from Pakistan.  Scientific Reports.  8:16088. 2018
• Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms.  Toxicon.  148:123-131. 2018
• Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.  Toxicology Letters.  280:159-170. 2017
• Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests.  Bioorganic & Medicinal Chemistry Letters.  27:2018-2022. 2017
• PROPUESTA DE INCORPORACIÓN DE LA NANOTECNOLOGÍA EN LA EDUCACIÓN FORMAL MEDIA EN COSTA RICA.  Revista MOMENTO.  193:17-28. 2017
• Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle.  PLoS ONE.  11. 2016
• A comprehensive view of the structural and functional alterations of extracellular matrix by snake venom metalloproteinases (SVMPs): Novel perspectives on the pathophysiology of envenoming.  Toxins.  8. 2016
• Hemorrhage caused by snake venom metalloproteinases: A journey of discovery and understanding.  Toxins.  8:93. 2016
• Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis.  PLoS Neglected Tropical Diseases.  10. 2016
• Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif.  Toxins.  8:292. 2016
• Viperid Envenomation Wound Exudate Contributes to Increased Vascular Permeability via a DAMPs/TLR-4 Mediated Pathway.  Toxins.  8:349. 2016
• Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.  Thrombosis and Haemostasis.  85:710-715. 2015
• Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage.  PLoS Neglected Tropical Diseases.  9. 2015
• The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay.  Toxicon.  93:41-50. 2014
• Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis.  Biochimie.  101:145-155. 2014
• Bothrops asper Metalloproteinase BaP1.  Handbook of Proteolytic Enzymes: Third Edition.  1:984-987. 2013
• Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase.  Journal of Proteomics.  80:250-267. 2013
• 160. Role of SVMPs, Matrikines and TLR4 in Snake Venom Induced Edema and Inflammation.  Toxicon.  60:177. 2012
• 192. Action of Venom Metalloproteinases on Basement Membranes: Pathogenesis of Hemorrhage and Blistering in Snakebite Envenomings.  Toxicon.  60:194-194. 2012
• Efficacy of IgG and F(ab′) 2 antivenoms to neutralize snake venom-induced local tissue damage as assessed by the proteomic analysis of wound exudate.  Journal of Proteome Research.  11:292-305. 2012
• Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture.  Muscle and Nerve.  47:202-212. 2012
• Mipartoxin-I, a novel three-finger toxin, is the major neurotoxic component in the venom of the redtail coral snake Micrurus mipartitus (Elapidae).  Toxicon.  60:851-863. 2012
• High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry.  Journal of Proteomics.  74:401-410. 2011
• Proteomics of wound exudate in snake venom-induced pathology: Search for biomarkers to assess tissue damage and therapeutic success.  Journal of Proteome Research.  10:1987-2005. 2011
• Role of collagens and perlecan in microvascular stability: Exploring the mechanism of capillary vessel damage by snake venom metalloproteinases.  PLoS ONE.  6. 2011
• Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?.  Toxicon.  55:166-170. 2010
• Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom.  Toxicon.  54:976-987. 2009
• Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins.  Journal of Proteome Research.  8:5120-5131. 2009
• Skin pathology induced by snake venom metalloproteinase: Acute damage, revascularization, and re-epithelization in a mouse ear model.  Journal of Investigative Dermatology.  128:2421-2428. 2008
• Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase.  Microvascular Research.  71:55-63. 2006
• Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: A biochemical and immunohistochemical study.  Archives of Biochemistry and Biophysics.  455:144-153. 2006
• Estrés y Depresión: Hipótesis Neuroendocrinas..  Humanitas.  1:66-78. 2005
• Hemorrhage induced by snake venom metalloproteinases: Biochemical and biophysical mechanisms involved in microvessel damage.  Toxicon.  45:997-1011. 2005
• Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: In vitro and in vivo gene expression analysis of the effects of the toxin.  Archives of Biochemistry and Biophysics.  441:1-15. 2005
• Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage.  Thrombosis and Haemostasis.  94:123-131. 2005
• Bothrops asper metalloproteinase BaP1 is inhibited by α 2-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy.  Toxicon.  43:213-217. 2004
• Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: Understanding the role of metalloproteinases in envenomation.  Toxicon.  43:417-424. 2004
• Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper.  Biochemical Pharmacology.  60:269-274. 2000