publicaciones seleccionadas
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artículo académico
- A functional role for snake envenomation wound exudate in local and systemically observed pathophysiology. Toxicon. 158:S1. 2019
- Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu. Toxicon. 18:1063-1069. 2019
- Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening. Toxins. 11:170. 2019
- Proteomic Analysis of Human Blister Fluids Following Envenomation by Three Snake Species in India: Differential Markers for Venom Mechanisms of Action. Toxins. 11:246. 2019
- Site mutation of residues in a loop surrounding the active site of a P[sbnd]I snake venom metalloproteinase abrogates its hemorrhagic activity. Biochemical and Biophysical Research Communications. 512:859-863. 2019
- Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis. Pharmaceutical and Pharmacological Letters. 10:115-118. 2018
- Excavating sponges from the Pacific of Central America, descriptions and a faunistic record . Zootaxa. 4370:451-491. 2018
- Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases. Journal of Proteomics. 317:1781-1794. 2018
- Metalloproteinases in disease: identification of biomarkers of tissue damage through proteomics. Expert Review of Proteomics. 15:967-982. 2018
- Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A2: Role of negatively charged phospholipids as potential membrane binding sites. Archives of Biochemistry and Biophysics. 148:56-64. 2018
- Preclinical evaluation of the neutralizing ability of a monospecific antivenom for the treatment of envenomings by Bothrops lanceolatus in Martinique. Toxicon. 148:50-55. 2018
- Systemic vascular leakage induced in mice by Russell’s viper venom from Pakistan. Scientific Reports. 8:16088. 2018
- Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms. Toxicon. 148:123-131. 2018
- Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles). Toxicon. 137:158-167. 2017
- Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests. Bioorganic & Medicinal Chemistry Letters. 27:2018-2022. 2017
- Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene. European Journal of Biochemistry. 267:5191-5197. 2017
- PROPUESTA DE INCORPORACIÓN DE LA NANOTECNOLOGÍA EN LA EDUCACIÓN FORMAL MEDIA EN COSTA RICA. Revista MOMENTO. 193:17-28. 2017
- Peptidomimetic hydroxamate metalloproteinase inhibitors abrogate local and systemic toxicity induced by Echis ocellatus (saw-scaled) snake venom. Toxicon. 135:40-49. 2017
- Physical and Compression Properties of Pellets Manufactured with the Biomass of Five Woody Tropical Species of Costa Rica Torrefied at Different Temperatures and Times. Energies. 10:1205. 2017
- Recycling and Elimination of Wastes obtained from Agriculture by using Nanotechnology: Nanosensors. International Journal of Biosensors & Bioelectronics. 3:368-375. 2017
- Steps to overcome the North-South divide in research relevant to climate-change policy and practice. Nature Climate Change. 7:21-27. 2017
- Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle. PLoS ONE. 11. 2016
- ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease Pooling Project of 19 Cohort Studies. JAMA Internal Medicine. 176:1155-1166. 2016
- A comprehensive view of the structural and functional alterations of extracellular matrix by snake venom metalloproteinases (SVMPs): Novel perspectives on the pathophysiology of envenoming. Toxins. 8. 2016
- Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. . Infection and Immunity. 84:856-865. 2016
- Hemorrhage caused by snake venom metalloproteinases: A journey of discovery and understanding. Toxins. 8:93. 2016
- Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis. PLoS Neglected Tropical Diseases. 10. 2016
- Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif. Toxins. 8:292. 2016
- Viperid Envenomation Wound Exudate Contributes to Increased Vascular Permeability via a DAMPs/TLR-4 Mediated Pathway. Toxins. 8:349. 2016
- Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage. Thrombosis and Haemostasis. 85:710-715. 2015
- Extracts of renealmia alpinia (rottb.) MAAS protect against lethality and systemic hemorrhage induced by bothrops asper venom: Insights from a model with extract administration before venom injection. Toxins. 7:1532-1543. 2015
- Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage. PLoS Neglected Tropical Diseases. 9. 2015
- Upwelling Increases Net Primary Production of Corals and Reef-Wide Gross Primary Production Along the Pacific Coast of Costa Rica. Frontiers in Marine Science. 2:113. 2015
- A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom. Toxicon. 87:81-91. 2014
- Circulating biomarkers of dairy fat and risk of incident stroke in U.S. men and women in 2 large prospective cohorts. The American Journal of Clinical Nutrition. 100:1437-1447. 2014
- Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus. Biochimie. 107:376-384. 2014
- Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom. Journal of Proteomics. 96:159-172. 2014
- The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay. Toxicon. 93:41-50. 2014
- Understanding structural and functional aspects of PII snake venom metalloproteinases: Characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis. Biochimie. 101:145-155. 2014
- Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom. Toxicon. 63:32-43. 2013
- Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico. Toxicon. 71:84-95. 2013
- Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P–I metalloproteinase from Bothrops asper snake venom: Insights from docking and molecular modeling. Toxicon. 71:41-48. 2013
- Investigación y desarrollo en ciencias exactas y naturales . Blood. 121:940-950. 2013
- Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase. Journal of Proteomics. 80:250-267. 2013
- Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model. Toxicon. 63:19-31. 2013
- 160. Role of SVMPs, Matrikines and TLR4 in Snake Venom Induced Edema and Inflammation. Toxicon. 60:177. 2012
- 192. Action of Venom Metalloproteinases on Basement Membranes: Pathogenesis of Hemorrhage and Blistering in Snakebite Envenomings. Toxicon. 60:194-194. 2012
- 222. Molecular Mechanisms Involved in PGE2 Release Induced by the Snake Venom Metalloproteinase BaP1 in Synoviocytes. Toxicon. 60:209-209. 2012
- Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis. Archives of Biochemistry and Biophysics. 418:13-24. 2012
- Diccionario histórico-toponímico de la Isla del Coco, Costa Rica. Revista de Biología Tropical. 60:1-14. 2012
- Efficacy of IgG and F(ab′) 2 antivenoms to neutralize snake venom-induced local tissue damage as assessed by the proteomic analysis of wound exudate. Journal of Proteome Research. 11:292-305. 2012
- Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture. Muscle and Nerve. 47:202-212. 2012
- Identification of new snake venom metalloproteinase inhibitors using compound screening and rational peptide design. ACS Medicinal Chemistry Letters. 3:540-543. 2012
- Isolation and biochemical, functional and structural characterization of a novel l-amino acid oxidase from Lachesis muta snake venom. Toxicon. 60:1263-1276. 2012
- Proteomics of wound exudate in snake venom-induced pathology: Search for biomarkers to assess tissue damage and therapeutic success. Journal of Proteome Research. 10:1987-2005. 2011
- Role of collagens and perlecan in microvascular stability: Exploring the mechanism of capillary vessel damage by snake venom metalloproteinases. PLoS ONE. 6. 2011
- Universidad de París Sur (Paris XI), Francia. PLoS ONE. 6. 2011
- Docencia universitaria en pregrado en ingenierías y tecnologías. Toxicon. 56:1059-1065. 2010
- Erratum to Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: Contributions to understanding snakebite envenomings and their treatment [Toxicon 54, 7, (2009), 1012-1028]. Toxicon. 55:1412-1413. 2010
- Isolation and biological characterization of Batx-I, a weak hemorrhagic and fibrinogenolytic PI metalloproteinase from Colombian Bothrops atrox venom. Toxicon. 56:936-943. 2010
- Experimental pathology of local tissue damage induced by Bothrops asper snake venom. Toxicon. 54:958-975. 2009
- Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom. Toxicon. 54:976-987. 2009
- Investigación y desarrollo en ingenierías y tecnologías. Toxicon. 54:1012-1028. 2009
- Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins. Journal of Proteome Research. 8:5120-5131. 2009
- Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom. Toxicon. 52:754-759. 2008
- Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper. Brazilian Journal of Medical and Biological Research. 41:12-17. 2008
- Skin pathology induced by snake venom metalloproteinase: Acute damage, revascularization, and re-epithelization in a mouse ear model. Journal of Investigative Dermatology. 128:2421-2428. 2008
- Snake venomics of the lesser antillean pit vipers bothrops caribbaeus and Bothrops lanceolatus: Correlation with toxicological activities and immunoreactivity of a heterologous antivenom. Journal of Proteome Research. 7:4396-4408. 2008
- Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations. Biologicals. 35:5-11. 2007
- Brucella abortus Uses a Stealthy Strategy to Avoid Activation of the Innate Immune System during the Onset of Infection. PLoS ONE. 2:e631. 2007
- Trends in snakebite envenomation therapy: Scientific, technological and public health considerations. Current Pharmaceutical Design. 13:2935-2950. 2007
- Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase. Microvascular Research. 71:55-63. 2006
- Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: Leukocyte recruitment and release of cytokines. Toxicon. 47:549-559. 2006
- Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells. Journal of Cellular Biochemistry. 94:520-528. 2005
- Hemorrhage induced by snake venom metalloproteinases: Biochemical and biophysical mechanisms involved in microvessel damage. Toxicon. 45:997-1011. 2005
- Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. Thrombosis and Haemostasis. 94:123-131. 2005
- Bothrops asper hemorrhagic proteinases. Handbook of Proteolytic Enzymes: Second Edition. 1:651-654. 2004
- Bothrops asper metalloproteinase BaP1 is inhibited by α 2-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy. Toxicon. 43:213-217. 2004
- Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: Understanding the role of metalloproteinases in envenomation. Toxicon. 43:417-424. 2004
- Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities. Enlace al artículo. 12:2273-2281. 2003
- Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom. Acta Crystallographica Section D: Biological Crystallography. 58:1034-1035. 2002
- Inhibitory properties of the anti-bothropic complex from Didelphis albiventris serum on toxic and pharmacological actions of metalloproteases and myotoxins from bothrops asper venom. Biochemical Pharmacology. 62:1521-1529. 2001
- Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae). Toxicon. 39:1863-1869. 2001
- Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice. International Journal of Experimental Pathology. 82:55-64. 2001
- Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment. Mediators of Inflammation. 9:213-221. 2000
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Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: Effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa
2 EDTA. American Journal of Tropical Medicine and Hygiene. 63:313-319. 2000 - Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Toxicon. 38:63-77. 2000
- Snake venom metalloproteinases: Their role in the pathogenesis of local tissue damage. Biochimie. 82:841-850. 2000
- Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. International Journal of Experimental Pathology. 79:245-254. 1998
- Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom. Toxicon. 36:1529-1538. 1998
- Isolation and characterization of a myotoxic phospholipase A(2) from the venom of the arboreal snake Bothriechis (Bothtops) schlegelii from Costa Rica. Archives of Biochemistry and Biophysics. 339:260-266. 1997
- Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice. Toxicon. 34:567-577. 1996
- Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper. Toxicon. 33:1103-1106. 1995