Rationale and design of a long term follow-up study of women who did and did not receive HPV 16/18 vaccination in Guanacaste, Costa Rica Artículo académico uri icon

Abstracto

  • Cervical cancer affects more than 500,000 women per year worldwide (1). Persistent infection with carcinogenic HPV is the necessary cause of cervical cancer (2), and also causes a subset of cancers of the anus, vulva, vagina, penis, and oropharynx (2), comprising approximately 70,000 additional cases of HPV-associated cancers per year (3). HPV 16 and 18 are responsible for 70% of cervical cancers (4) and for most cases of HPV-driven cancers at the other anatomical sites (5;6). HPV prophylactic vaccines have the potential to dramatically reduce the burden of HPV-associated disease if incorporated into cervical cancer prevention programs, especially in developing countries.

fecha de publicación

  • 2015

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