The eigenvalues of the light-front QCD Hamiltonian, quantized at fixed light-front time τ = t + z/c, predict the hadronic mass spectrum and the corresponding eigensolutions provide the light-front wavefunctions which describe hadron structure. More generally, we show that the valence Fockstate wavefunctions of the light-front QCD Hamiltonian satisfy a singlevariable relativistic equation of motion, analogous to the nonrelativistic radial Schr¨odinger equation, with an effective confining potential U which systematically incorporates the effects of higher quark and gluon Fock states. We outline a method for computing the required potential from first principles in QCD. The holographic mapping of gravity in AdS space to QCD, quantized at fixed light-front time, yields the same light front Schr¨odinger equation; in fact, the soft-wall AdS/QCD approach provides a model for the light-front potential which is color-confining and reproduces well the light-hadron spectrum. One also derives via light-front holography a precise relation between the bound-state amplitudes in the fifth dimension of AdS space and the boost-invariant light-front wavefunctions describing the internal structure of hadrons in physical space-time. The elastic and transition form factors of the pion and the nucleons are found to be well described in this framework. The light-front AdS/QCD holographic approach thus gives a frame-independent first approximation of the color-confining dynamics, spectroscopy, and excitation spectra of relativistic light-quark bound states in QCD.