artículo académico

• Deficient skeletal muscle regeneration after injury induced by a Clostridium perfringens strain associated with gas gangrene.  Infection and Immunity.  2019
• Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms.  PLoS Neglected Tropical Diseases.  11:e0005793. 2017
• Expanding the neutralization scope of the EchiTAb-plus-ICP antivenom to include venoms of elapids from Southern Africa.  Toxicon.  125:59-64. 2017
• Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom.  Toxicon.  132:55-61. 2017
• Identification of B cell recognized linear epitopes in a snake venom serine proteinase from the central American bushmaster Lachesis stenophrys.  Toxicon.  140:72-82. 2017
• Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.  European Journal of Biochemistry.  267:5191-5197. 2017
• Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2.  Toxicology Letters.  257:60-71. 2016
• Bacterial Sphingomyelinases and Phospholipases as Virulence Factors.  Microbiology and Molecular Biology Reviews.  80:597-628. 2016
• Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom.  Toxicon.  122:152-159. 2016
• Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis.  Characterization of a basic phospholipase A2-homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarara chica) from Argentina.  9:ra64. 2016
• Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.  Toxicon.  122:7-25. 2016
• Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NF kappa B Activation.  PLoS ONE.  9:e86475. 2014
• Internalization of C lostridium perfringens α-toxin leads to ERK activation and is involved on its cytotoxic effect.  Cellular Microbiology.  16:535-547. 2014
• Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis.  Journal of Proteomics.  89:112-123. 2013
• Aprendizaje cooperativo en un curso de bioquímica: opinión de estudiantes y efecto en su rendimiento académico.  Actualidades Investigativas en Educación.  12:1-26. 2012
• Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.  Archives of Biochemistry and Biophysics.  418:13-24. 2012
• Reactive Oxygen Species and the MEK/ERK Pathway Are Involved in the Toxicity of Clostridium perfringens -Toxin, a Prototype Bacterial Phospholipase C.  Journal of Infectious Diseases.  206:1218-1226. 2012
• Snake venomics across genus Lachesis. Ontogenetic changes in the venom composition of Lachesis stenophrys and comparative proteomics of the venoms of adult Lachesis melanocephala and Lachesis acrochorda.  Journal of Proteomics.  77:280-297. 2012
• Effects of bilayer composition and physical properties on the phospholipase C and sphingomyelinase activities of Clostridium perfringens α-toxin.  Biochimica et Biophysica Acta - Biomembranes.  1808:279-286. 2011
• Profiling the venom gland transcriptomes of costa rican snakes by 454 pyrosequencing.  BMC Genomics.  12. 2011
• Unexpected wide substrate specificity of C. perfringens α-toxin phospholipase C.  Biochimica et Biophysica Acta - Biomembranes.  1808:2618-2627. 2011
• Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).  Journal of Proteome Research.  10:1816-1827. 2011
• Comparison of a nontoxic variant of Clostridium perfringens α-toxin with the toxic wild-type strain.  Acta Crystallographica Section D: Biological Crystallography.  66:1067-1074. 2010
• Snake venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America.  Journal of Proteome Research.  9:528-544. 2010
• Enlace al artículo.  Journal of Proteome Research.  9:564-577. 2009
• Neutralization of venom-induced hemorrhage by equine antibodies raised by immunization with a plasmid encoding a novel P-II metalloproteinase from the lancehead pitviper Bothrops asper.  Vaccine.  27:460-466. 2009
• Phospholipase C and sphingomyelinase activities of the Clostridium perfringens α-toxin.  Chemistry and Physics of Lipids.  159:51-57. 2009
• Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management.  Journal of Proteomics.  72:227-240. 2009
• Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.  Journal of Proteomics.  72:165-182. 2009
• Studies on the venom proteome of Bothrops asper: Perspectives and applications.  Toxicon.  54:938-948. 2009
• The NanI and NanJ Sialidases of Clostridium perfringens Are Not Essential for Virulence.  Infection and Immunity.  77:4421-4428. 2009
• Immunization with cDNA of a novel P-III type metalloproteinase from the rattlesnake Crotalus durissus durissus elicits antibodies which neutralize 69% of the hemorrhage induced by the whole venom.  Toxicon.  52:302-308. 2008
• Snake Venomics of the Lancehead Pitviper Bothrops asper: Geographic, Individual, and Ontogenetic Variations.  Journal of Proteome Research.  7:3556-3571. 2008
• Isolation, characterization and molecular cloning of AnMIP, a new α-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae).  Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology.  146:60-68. 2007
• A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.  Journal of Biological Chemistry.  280:26680-26689. 2005
• A Cellular UDP-glucose Deficiency Causes Overexpression of Glucose/Oxygen-regulated Proteins Independent of the Endoplasmic Reticulum Stress Elements.  Journal of Biological Chemistry.  279:21724-21731. 2004
• Effects of Clostridium perfringens phospholipase C in mammalian cells.  Anaerobe.  10:115-123. 2004
• A point mutation in the UDP-glucose pyrophosphorylase gene results in decreases of UDP-glucose and inactivation of glycogen synthase.  Biochemical Journal.  370:995-1001. 2003
• Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities.  Enlace al artículo.  12:2273-2281. 2003
• Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene.  Toxicon.  42:979-986. 2003
• Ocatin. A Novel Tuber Storage Protein from the Andean Tuber Crop Oca with Antibacterial and Antifungal Activities.  Plant Physiology.  128:1291-1302. 2002
• Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A2 homologue.  Disturbance compensation on uncertain systems: feedforward control design for stable systems.  34:1268-1278. 2002
• AHA scientific statement: summary of the scientific conference on dietary fatty acids and cardiovascular health: conference summary from the nutrition committee of the American Heart Association.  The Journal of Nutrition.  131:1322-1326. 2001
• AHA scientific statement: summary of the scientific conference on dietary fatty acids and cardiovascular health: conference summary from the nutrition committee of the American Heart Association.  The Journal of Nutrition.  131:1322-1326. 2001
• Tyrosine 331 and phenylalanine 334 in Clostridium perfringens α-toxin are essential for cytotoxic activity.  FEBS Letters.  495:172-177. 2001
• Identification of Residues in the Carboxy-Terminal Domain of Clostridium perfringens α-Toxin (Phospholipase C) Which Are Required for Its Biological Activities.  Archives of Biochemistry and Biophysics.  384:24-30. 2000
• Elapid venom toxins: Multiple recruitments of ancient scaffolds.  European Journal of Biochemistry.  259:225-234. 1999
• UDP-glucose Deficiency Causes Hypersensitivity to the Cytotoxic Effect of Clostridium perfringens Phospholipase C.  Journal of Biological Chemistry.  273:24433-24438. 1998
• A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus.  Toxicon.  35:573-581. 1997
• Cellular UDP-Glucose Deficiency Caused by a Single Point Mutation in the UDP-Glucose Pyrophosphorylase Gene.  Journal of Biological Chemistry.  272:23784-23791. 1997
• Isolation and characterization of a myotoxic phospholipase A(2) from the venom of the arboreal snake Bothriechis (Bothtops) schlegelii from Costa Rica.  Archives of Biochemistry and Biophysics.  339:260-266. 1997
• Universidad de París VII Denis Diderot, Francia.  Toxicon.  35:1605-1616. 1997
• Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from Micrurus nigrocinctus nigrocinctus (coral snake) venom.  Toxicon.  34:369-380. 1996
• Characterization of multiple nicotinic acetylcholine receptor-binding proteins and phospholipases A2 from the venom of the coral snake Micrurus nigrocinctus.  FEBS Letters.  380:29-32. 1996
• Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect.  Archives of Biochemistry and Biophysics.  312:336-339. 1994
• Electrophoretic and immunochemical studies of Micrurus snake venoms.  Toxicon.  32:713-723. 1994
• Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies.  Toxicon.  32:695-712. 1994