Efecto del extracto acuoso de hojas de Licania platypus (Hemsl.) Fritsh. Sobre la protección gástrica y la motilidad gastrointestinal. Artículo académico uri icon


  • Licania platypus is a species widely distributed in tropical countries. Traditionally, it has been used in Central America for a variety of health problems, especially gastrointestinal problems. Aim: To investigate gastric antiulcer activity and gastrointestinal motility effect of Licania platypus leaves aqueous extract. Methods: Gastric lesions were induced by ethanol and indomethacin models; also other parameters were analyzed in pylorus-ligated model. Furthermore, was evaluated the effect on gastrointestinal motility using phenol red. Results: Oral administration of aqueous extract (1000 mg/kg) significantly reduced the area of gastric lesions (p < 0,05) on both models. It was observed a significantly increased the gastric secretion volume and gastric mucus, whereas decreased total acidity and lipid peroxidation (p < 0,05). The aqueous extract of Licania platypus reduced the rate of gastric emptying (p < 0,05), but did not show any effect on intestinal transit. Conclusion: Licania platypus aqueous extract has a gastroprotective effect in different acute ulcer induction models and reducing the rate of gastric emptying. The activities proved in this study contribute ethnopharmacological knowledge attributed to Licania platyus.

fecha de publicación

  • 2018