Despite the worldwide efforts to eradicate malaria, it continues to be a global health problem, which is why we are currently searching for active components of natural origin. Ticodendron incognitum the only species of the Ticodendraceae family was discovered in Costa Rica in 1989 and currently there are no reports on its chemical composition or biological activity. Therefore, the objective of this study was to perform a phytochemical analysis of the crude extract, the root, bark and leaves of the plant, and the determination of the antimalarial activity of the fractions obtained from this phytochemical detection. The qualitative analysis showed the presence of terpenes, coumarins, anthocyanins, flavonoids, phenols, tannins, reducing compounds, triterpenes and sterols. In addition, IC50 values lower than 50 μg/ml, considered as active against the strain of P. berghei NK65, were obtained in the ethereal extract of the root and bark and in the hydrolyzed aqueous extract of the root. This type of studies supports the interest in continuing to identify new components that can be used as a possible treatment for malaria. Based on the results obtained, it bring on us to carry out studies in the purification and characterization of the active components, as well as in vivo studies that we have already begun, that will allow us to confirm these interesting findings.
