Non-enzymatic acetylation of proteins by aspirin as protection against the secondary complications of diabetes mellitus
Artículo académicoValor fecha/hora
The non-enzymic glycosylation of proteins has been implicated as a contributing pathogenia in the secondary complications of diabetes mellitus. The reversible acetylation of proteins by aspirin could slow down the advance of the biochemical lesion in well-controlled patients. The rate of acetylation of albumin by aspirin at 37 degrees C and pH = 7.30 was found to proceed two orders of magnitude faster than the glycosylation, providing a basis for therapeutic possibilities for the complications of diabetes mellitus.
