Cytotoxic Cardiac Glycosides and Other Compounds from Asclepias Syriaca Artículo académico uri icon

Abstracto

  • Phytochemical investigation of the dried biomass of Asclepias syriaca afforded five new compounds (1−5), along with 19 known structures. Overall, the secondary metabolites isolated and identified from this plant showed a wide structural diversity including pentacyclic triterpenes, cardiac glycosides, flavonoid glycosides, lignans, a phenylethanoid, and a glycosylated megastigmane. In addition, the isolates were tested against the cancer breast cell line Hs578T, and those showing IC50 values lower than 50 μM (1 and 6−9) were further investigated in three additional breast cancer cell lines (MCF-7, T47D, and Sk-Br-3) and the normal breast cell line Hs578Bst.

fecha de publicación

  • 2012